SecurityIRWD / Ironwood Pharmaceuticals, Inc. (46333X108)
IndustryPharmaceutical Preparations
Institutional Owners165
Institutional Shares149,108,768 - 107.13%
Institutional Value$ 130,652,488,000 USD
Related 46333XAD0 / Ironwood Pharmaceuticals, Inc. DBCV 2.250% 6/1

Institutional Stock Ownership and Shareholders

IRWD / Ironwood Pharmaceuticals, Inc. Institutional Ownership

Ironwood Pharmaceuticals, Inc. (NASDAQ:IRWD) has 165 institutional investors and shareholders that have filed 13D/G or 13F forms with the Securities Exchange Commission (SEC). These institutions hold a total of 149,108,768 shares. Largest shareholders include Wellington Management Group LLP, Vanguard Group Inc, BlackRock Inc., Price T Rowe Associates Inc /md/, Henderson Group Plc, Janus Capital Management Llc, Ubs Asset Management Americas Inc, BlackRock Fund Advisors, Brown Capital Management Llc, and EcoR1 Capital, LLC.
Ironwood Pharmaceuticals, Inc. (NASDAQ:IRWD) ownership structure shows current positions in the company by institutions and funds, as well as latest changes in position size. Major shareholders can include individual investors, mutual funds, hedge funds, or institutions. The Schedule 13D indicates that the investor holds more than 5% of the company and intends to actively pursue a change in business strategy. Schedule 13G indicates a passive investment of over 5%. Green rows indicate new positions. Red rows indicate closed positions. Click the link icon to see the full transaction history.

File DateFormInvestor Opt Prev
Shares
Current
Shares
Change
(Percent)
Prev Value
($1000)
Current Value
($1000)
Change
(Percent)
2018-08-14 13F-HR PRICE T ROWE ASSOCIATES INC /MD/ 12,210,451 11,168,591 -8.53 188,407 213,543 13.34
2018-07-30 13F-HR Daiwa Securities Group Inc. 748 748 0.00 12 14 16.67
2018-05-11 13F-HR CITIGROUP INC 156,014 95,633 -38.70 2,338 1,475 -36.91
2018-08-10 13F-HR PNC FINANCIAL SERVICES GROUP, INC. 96 17,013 17,621.88 1 325 32,400.00
2017-08-10 13F-HR Century Capital Management, LLC 36,443 27,956 -23.29 622 528 -15.11
2018-08-14 13F-HR MANUFACTURERS LIFE INSURANCE COMPANY, THE 100,509 102,797 2.28 1,552 1,965 26.61
2018-08-10 13F-HR Pacad Investment Ltd. 100 0 -100.00 2 0 -100.00
2018-02-09 13F-HR RidgeWorth Capital Management LLC 25,074 81,044 223.22 395 1,215 207.59
2018-08-03 13F-HR NOMURA ASSET MANAGEMENT CO LTD 0 0 0 0
2018-08-13 13F-HR TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 616,747 616,747 0.00 9,516 11,792 23.92
2018-07-09 13F-HR Fisher Asset Management, LLC 579,868 211,240 -63.57 8,947 4,039 -54.86
2018-08-13 13F-HR WOLVERINE TRADING, LLC Call 20,600 20,600 0.00 318 318 0.00
2018-08-17 13F-HR/A NOMURA HOLDINGS INC 0 127,765 0 2,443
2018-08-09 13F-HR BlackRock Inc. 11,238,427 11,805,955 5.05 173,408 225,728 30.17
2018-08-14 13F-HR SUSQUEHANNA INTERNATIONAL GROUP, LLP Call 57,600 305,900 431.08 889 5,849 557.93
2018-08-14 13F-HR ORBIMED ADVISORS LLC Call 150,000 150,000 0.00 2,315 2,868 23.89
2018-08-09 13F-HR Swiss National Bank 223,500 238,300 6.62 3,449 4,556 32.10
2018-08-10 13F-HR CITIGROUP INC Put 3,200 1,700 -46.88 49 33 -32.65
2018-08-13 13F-HR SENZAR ASSET MANAGEMENT, LLC 649,824 0 -100.00 10,026 0 -100.00
2018-08-14 13F-HR BARCLAYS PLC 33,180 10,149 -69.41 511 194 -62.04
2018-08-14 13F-HR CLEARBRIDGE, LLC 781,339 0 -100.00 12,056 0 -100.00
2018-07-25 13F-HR BNP PARIBAS ARBITRAGE, SA 28,928 7,245 -74.96 446,359 138,524 -68.97
2018-02-14 13F-HR CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. 55,869 58,269 4.30 880 872 -0.91
2018-08-10 13F-HR Cutler Group LP 0 570 0 10
2018-07-17 13F-HR FOX RUN MANAGEMENT, L.L.C. 12,569 0 -100.00 194 0 -100.00
2018-08-15 13F-HR Metlife Investment Advisors, Llc 63,682 63,682 0.00 983 1,218 23.91
2018-08-09 13F-HR/A Smith Asset Management Group LP 15,380 15,370 -0.07 237 294 24.05
2018-08-02 13F-HR/A ALPS ADVISORS INC 181,590 198,897 9.53 2,802 3,803 35.72
2018-08-13 13F-HR OPPENHEIMER FUNDS INC 2,586,050 2,872,640 11.08 39,903 54,925 37.65
2018-08-14 13F-HR LOOMIS SAYLES & CO L P 1,533,753 1,528,525 -0.34 23,666 29,225 23.49
2018-08-13 13F-HR OXFORD ASSET MANAGEMENT 71,158 0 -100.00 1,098 0 -100.00
2018-08-14 13F-HR QS Investors, LLC 2,900 2,900 0.00 45 55 22.22
2018-08-14 13F-HR GEODE CAPITAL MANAGEMENT, LLC 1,282,719 1,423,792 11.00 19,792 27,222 37.54
2018-08-14 13F-HR Clearbridge Investments, LLC 82 0 -100.00 1 0 -100.00
2018-08-27 13F-HR Farmers National Bank 450 9
2018-08-14 13F-HR DekaBank Deutsche Girozentrale 59,850 19,850 -66.83 910 376 -58.68
2018-08-10 13F-HR Artal Group S.A. 216,879 216,879 0.00 3,346 4,147 23.94
2018-08-14 13F-HR DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main 328,993 0 -100.00 5,076 0 -100.00
2018-08-14 13F-HR Marshall Wace North America L.P. 219,697 4,201
2018-08-03 13F-HR Gerber Kawasaki Wealth & Investment Management 10,259 0 -100.00 158 0 -100.00
2018-08-14 13F-HR Jacobi Capital Management LLC 4,300 4,300 0.00 61 82 34.43
2018-08-15 13F-HR GLENMEDE TRUST CO NA 2,110 2,029 -3.84 31 39 25.81
2018-05-10 13F-HR DENVER INVESTMENT ADVISORS LLC 21,296 0 -100.00 319 0 -100.00
2018-08-14 13F-HR Jefferies Group LLC Put 75,000 1,434
2018-07-30 13F-HR Hemenway Trust Co LLC 13,630 0 -100.00 210 0 -100.00
2018-05-11 13F-HR Delpha Capital Management, Llc 95 0 -100.00 1 0 -100.00
2018-08-13 13F-HR GROUP ONE TRADING, L.P. Call 1,400 100,900 7,107.14 22 1,929 8,668.18
2018-08-14 13F-HR Park West Asset Management LLC 630,593 807,941 28.12 9,730 15,448 58.77
2018-08-10 13F-HR Quantitative Investment Management, LLC 0 29,100 0 556
2018-07-31 13F-HR TD ASSET MANAGEMENT INC 241,883 228,683 -5.46 3,732 4,372 17.15
2018-08-14 13F-HR TIAA CREF INVESTMENT MANAGEMENT LLC 405,827 305,643 -24.69 6,262 5,844 -6.68
2018-08-10 13F-HR Cutler Group LP Put 1,200 2,500 108.33 0 2
2018-08-14 13F-HR DEUTSCHE BANK AG\ 271,131 258,981 -4.48 4,182 4,950 18.36
2018-09-19 13F-HR ROYAL LONDON ASSET MANAGEMENT LTD 139,080 2,659
2018-08-14 13F-HR FLAGSHIP HARBOR ADVISORS, LLC 300 5
2018-08-03 13F-HR STATE OF WISCONSIN INVESTMENT BOARD 578,130 435,030 -24.75 8,921 8,318 -6.76
2018-08-14 13F-HR CREDIT SUISSE AG/ 1,547,413 1,314,550 -15.05 23,877 25,133 5.26
2018-08-15 13F-HR/A PUTNAM INVESTMENTS LLC 189,046 189,046 0.00 3,614 3,614 0.00
2018-08-08 13F-HR BAILARD, INC. 23,000 28,500 23.91 355 545 53.52
2018-08-14 13F-HR BANK OF AMERICA CORP /DE/ Call 54,500 97,000 77.98 841 1,855 120.57
2018-08-14 13F-HR Parallax Volatility Advisers, L.P. 48,366 178,266 268.58 746 3,408 356.84
2018-07-26 13F-HR Plante Moran Financial Advisors, LLC 122 79 -35.25 2 2 0.00
2018-07-30 13F-HR Broderick Brian C 55,000 377,933 587.15 849 7,226 751.12
2018-08-14 13F-HR/A CITADEL ADVISORS LLC 245,195 508,318 107.31 3,783 9,719 156.91
2018-07-16 13F-HR V Wealth Management,LLC 0 13,499 0 258
2018-07-11 13F-HR Xact Kapitalforvaltning AB 22,655 22,155 -2.21 350 424 21.14
2018-08-14 13F-HR BVF INC/IL 5,542,400 606,715 -89.05 85,519 11,600 -86.44
2018-08-14 13F-HR Adage Capital Partners GP LLC 1,875,000 1,875,000 0.00 28,931 35,850 23.92
2018-08-10 13F-HR YorkBridge Wealth Partners, LLC 2,635 0 -100.00 45 0 -100.00
2018-08-10 13F-HR HENDERSON GROUP PLC 8,127,288 8,067,938 -0.73 125,404 154,259 23.01
2017-02-10 13F-HR BlackRock Fund Advisors 5,750,071 6,452,010 12.21 91,311 98,651 8.04
2018-08-13 13F-HR Global Retirement Partners, Llc 160 0 -100.00 2 0 -100.00
2018-09-18 13F-HR/A NORTHERN TRUST CORP 1,561,766 1,641,866 5.13 24,099 31,392 30.26
2018-08-14 13F-HR GUGGENHEIM CAPITAL LLC 188,974 172,142 -8.91 2,915 3,291 12.90
2018-02-14 13F-HR AHL Partners LLP 19,434 291
2017-02-10 13F-HR BlackRock Advisors LLC 330,843 424,864 28.42 5,254 6,496 23.64
2018-08-01 13F-HR WELLS FARGO & COMPANY/MN 220,113 91,021 -58.65 3,397 1,740 -48.78
2018-08-13 13F-HR GROUP ONE TRADING, L.P. 3,696 0 -100.00 57 0 -100.00
2018-08-14 13F-HR/A CITADEL ADVISORS LLC Put 0 21,000 0 402
2018-08-14 13F-HR Sarissa Capital Management LP 3,367,100 3,367,100 0.00 51,954 64,378 23.91
2018-08-09 13F-HR Tortoise Investment Management, LLC 3,293 3,293 0.00 51 63 23.53
2018-08-01 13F-HR BNP Paribas Investment Partners S.A. 1,704,974 1,353,742 -20.60 26,308 25,884 -1.61
2018-07-30 13F-HR SIMPLEX TRADING, LLC 40,430 0 -100.00 623 0 -100.00
2018-07-17 13F-HR Legacy Financial Advisors, Inc. 533 599 12.38 8 13 62.50
2018-08-14 13F-HR Paloma Partners Management Co 61,812 0 -100.00 954 0 -100.00
2018-08-10 13F-HR Itau Unibanco Holding S.A. 3,453 2,929 -15.18 53 56 5.66
2018-08-14 13F-HR Holocene Advisors, Lp 16,084 0 -100.00 248 0 -100.00
2017-02-07 13F-HR WILLIAM HARRIS INVESTORS INC 19,662 19,662 0.00 312 301 -3.53
2018-08-14 13F-HR Atika Capital Management LLC 0 164,000 0 3,135
2018-08-13 13F-HR GROUP ONE TRADING, L.P. Put 2,100 14,800 604.76 32 283 784.38
2018-07-24 13F-HR MEEDER ASSET MANAGEMENT INC 0 9,703 0 185,521
2018-08-15 13F-HR JANE STREET GROUP, LLC 11,670 0 -100.00 180 0 -100.00
2018-08-14 13F-HR BOOTHBAY FUND MANAGEMENT, LLC 14,043 0 -100.00 217 0 -100.00
2018-08-10 13F-HR GREAT WEST LIFE ASSURANCE CO /CAN/ 14,842 14,842 0.00 229 284 24.02
2018-08-14 13F-HR GOLDMAN SACHS GROUP INC Put 0 34,000 0 650
2018-08-14 13F-HR GOLDMAN SACHS GROUP INC Call 125,700 0 -100.00 1,940 0 -100.00
2018-08-10 13F-HR CITIGROUP INC Call 100 13,500 13,400.00 2 258 12,800.00
2018-08-23 13F-HR/A BROOKSIDE CAPITAL MANAGEMENT LLC 291,652 0 -100.00 4,500 0 -100.00
2018-07-18 13F-HR Sawyer & Company, Inc 41,000 41,000 0.00 633 784 23.85
2018-08-15 13F-HR PLATINUM INVESTMENT MANAGEMENT LTD 104,500 80,700 -22.78 1,612 1,543 -4.28
2018-08-06 13F-HR STRS OHIO 500 4,700 840.00 7 89 1,171.43
2018-08-13 13F-HR WOLVERINE TRADING, LLC Put 10,000 10,000 0.00 154 154 0.00
2018-08-02 13F-HR SECTOR GAMMA AS 1,121,135 423,850 -62.19 17,299 8,104 -53.15
2018-08-14 13F-HR BROWN CAPITAL MANAGEMENT LLC 6,264,825 6,305,456 0.65 96,666 120,560 24.72
2018-08-10 13F-HR NEW YORK STATE COMMON RETIREMENT FUND 1,409,457 1,455,101 3.24 21,748 27,822 27.93
2018-08-13 13F-HR Advisor Group, Inc. 171 171 0.00 2 3 50.00
2018-08-10 13F-HR Employees Retirement System of Texas 105,000 84,000 -20.00 1,620 1,606 -0.86
2018-08-14 13F-HR BALYASNY ASSET MANAGEMENT LLC 13,672 17,412 27.36 211 333 57.82
2018-07-30 13F-HR First Capital Advisors Group, LLC. 2,901 0 -100.00 45 0 -100.00
2018-08-07 13F-HR Trexquant Investment LP 61,559 46,311 -24.77 950 885 -6.84
2018-08-14 13F-HR UBS ASSET MANAGEMENT AMERICAS INC 5,776,762 6,461,130 11.85 89,135,436 123,536,805 38.59
2018-08-13 13F-HR PARAMETRIC PORTFOLIO ASSOCIATES LLC 70,417 82,448 17.09 1,087 1,576 44.99
2018-08-07 13F-HR SG Americas Securities, LLC 8,944 30,811 244.49 138 589 326.81
2018-08-14 13F-HR MILLENNIUM MANAGEMENT LLC 0 67,305 0 1,287
2018-08-03 13F-HR THOMPSON DAVIS & CO., INC. 2,450 47
2018-08-14 13F-HR MORGAN STANLEY 337,345 361,036 7.02 5,205 6,903 32.62
2018-05-11 13F-HR CITIGROUP INC Call 5,800 100 -98.28 87 2 -97.70
2018-08-15 13F-HR METROPOLITAN LIFE INSURANCE CO/NY 43,841 44,771 2.12 676,467 856,022 26.54
2018-08-14 13F-HR SUSQUEHANNA INTERNATIONAL GROUP, LLP 0 165,576 0 3,166
2018-08-08 13F-HR Russell Investments Group, Ltd. 79,692 86,101 8.04 1,230 1,646 33.82
2018-08-14 13F-HR Parallax Volatility Advisers, L.P. Put 0 11,500 0 220
2018-07-31 13F-HR Rockefeller Capital Management L.p. 2,678 2,678 0.00 41 51 24.39
2018-08-15 13F-HR CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM 221,800 220,825 -0.44 3,422 4,222 23.38
2018-08-06 13F-HR MACKAY SHIELDS LLC 56,269 48,469 -13.86 868 927 6.80
2018-08-22 13F-HR McAdam, LLC 30 1
2018-02-02 13F-HR ROCKEFELLER FINANCIAL SERVICES INC 2,678 2,678 0.00 42 40 -4.76
2018-08-13 13F-HR TOCQUEVILLE ASSET MANAGEMENT L.P. 29,612 28,804 -2.73 457 551 20.57
2018-08-14 13F-HR Schonfeld Strategic Advisors LLC 76,195 0 -100.00 1,176 0 -100.00
2018-08-06 13F-HR Zurcher Kantonalbank (Zurich Cantonalbank) 9,010 9,010 0.00 139 172 23.74
2018-08-14 13F-HR BANK OF AMERICA CORP /DE/ 213,730 197,409 -7.64 3,298 3,775 14.46
2018-08-10 13F-HR OPPENHEIMER & CO INC 34,000 0 -100.00 525 0 -100.00
2018-08-07 13F-HR IFP Advisors, Inc 0 61 0 1
2018-08-13 13F-HR HAP Trading, LLC Call 271,900 632
2018-08-22 13F-HR PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 108,195 120,370 11.25 1,669 2,301 37.87
2018-08-13 13F-HR Ameritas Investment Partners, Inc. 11,821 11,821 0.00 182 226 24.18
2018-08-14 13F-HR GOLDMAN SACHS GROUP INC 817,807 938,263 14.73 12,619 17,940 42.17
2018-08-10 13F-HR UNITED SERVICES AUTOMOBILE ASSOCIATION 336,163 15,363 -95.43 5,187 6,284 21.15
2018-08-10 13F-HR NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 270 270 0.00 4 5 25.00
2018-08-14 13F-HR JP Morgan Chase & Co 97,992 574,669 486.44 1,511 10,988 627.20
2018-05-11 13F-HR CITIGROUP INC Put 2,500 3,200 28.00 37 49 32.43
2017-08-11 13F-HR BLUE JAY CAPITAL MANAGEMENT, LLC 675,000 470,000 -30.37 11,516 8,874 -22.94
2018-08-14 13F-HR VANGUARD GROUP INC 11,480,383 11,947,777 4.07 177,141 228,441 28.96
2018-08-14 13F-HR Capital World Investors 2,030,000 2,030,000 0.00 31,323 38,814 23.92
2018-08-14 13F-HR TEACHERS ADVISORS INC 284,451 255,191 -10.29 4,389 4,879 11.16
2018-08-13 13F-HR PRUDENTIAL FINANCIAL INC 14,374 14,884 3.55 222 285 28.38
2018-08-14 13F-HR SYMPHONY ASSET MANAGEMENT LLC 113,100 2,162
2018-08-14 13F-HR SUSQUEHANNA INTERNATIONAL GROUP, LLP Put 35,700 24,900 -30.25 551 476 -13.61
2018-08-14 13F-HR JP Morgan Chase & Co Put 0 76,500 0 1,463
2018-07-20 13F-HR Steward Partners Investment Advisory, Llc 250 250 0.00 3 5 66.67
2018-08-14 13F-HR EVENTIDE ASSET MANAGEMENT, LLC 192,000 192,000 0.00 2,963 3,671 23.89
2018-08-02 13F-HR PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 24,883 24,883 0.00 384 476 23.96
2018-07-30 13F-HR SIMPLEX TRADING, LLC Call 301 1,046 247.51 31 1,999 6,348.39
2017-05-16 13F-HR JANUS CAPITAL MANAGEMENT LLC 12,433,680 7,925,901 -36.25 190,128 135,213 -28.88
2018-08-10 13F-HR CITIGROUP INC 95,633 26,333 -72.46 1,475 504 -65.83
2018-08-14 13F-HR Voya Investment Management LLC 59,506 55,769 -6.28 918 1,066 16.12
2018-07-30 13F-HR SIMPLEX TRADING, LLC Put 35 5 -85.71 9 9 0.00
2018-08-03 13F-HR Engineers Gate Manager LP 111,861 0 -100.00 1,726 0 -100.00
2018-08-14 13F-HR Crestline Management, LP 30,600 585
2018-08-14 13F-HR WOLVERINE ASSET MANAGEMENT LLC Call 3,900 0 -100.00 60 0 -100.00
2018-07-30 13F-HR Aperio Group, LLC 15,781 21,185 34.24 244 405 65.98
2018-08-10 13F-HR Legal & General Group Plc 52,167 49,927 -4.29 805 955 18.63
2018-08-08 13F-HR US BANCORP \DE\ 72 72 0.00 1 1 0.00
2018-08-03 13F-HR Financial Architects, Inc Call 1,000 0 -100.00 15 0 -100.00
2018-08-15 13F-HR GRANAHAN INVESTMENT MANAGEMENT INC/MA 456,100 520,888 14.20 7,038 9,959 41.50
2018-07-13 13F-HR BANK OF MONTREAL /CAN/ 2,678 5,027 87.71 42 96 128.57
2018-08-14 13F-HR CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 204,946 212,015 3.45 3,162 4,054 28.21
2018-07-31 13F-HR LOS ANGELES CAPITAL MANAGEMENT & EQUITY RESEARCH INC 42,120 16,315 -61.27 650 312 -52.00
2018-08-08 13F-HR AMERICAN INTERNATIONAL GROUP INC 86,090 90,250 4.83 1,328 1,726 29.97
2018-08-02 13F-HR FIRST TRUST ADVISORS LP 0 49,794 0 952
2018-08-13 13F-HR WESTFIELD CAPITAL MANAGEMENT CO LP 1,392,231 26,619
2017-02-14 13F-HR EverPoint Asset Management, LLC 1,900,000 825,000 -56.58 30,172 12,614 -58.19
2018-07-30 13F-HR Raymond James Financial Services Advisors, Inc. 11,483 0 -100.00 177 0 -100.00
2018-08-14 13F-HR BARCLAYS PLC Put 0 1,000 0 19
2018-08-14 13F-HR ORBIMED ADVISORS LLC 2,929,250 2,929,250 0.00 45,198 56,007 23.91
2018-08-14 13F-HR EcoR1 Capital, LLC 5,885,583 6,250,073 6.19 90,815 119,501 31.59
2018-08-14 13F-HR/A CITADEL ADVISORS LLC Call 16,000 29,600 85.00 247 566 129.15
2018-08-13 13F-HR ALLIANCEBERNSTEIN L.P. 202,560 202,560 0.00 3,126 3,873 23.90
2018-08-06 13F-HR RHUMBLINE ADVISERS 127,657 133,892 4.88 1,970 2,560 29.95
2018-08-13 13F-HR Quantbot Technologies LP 0 2,779 0 53
2018-07-18 13F-HR NISA INVESTMENT ADVISORS L.L.C. 6,810 6,810 0.00 105 130 23.81
2017-02-10 13F-HR BlackRock Investment Management, LLC 486,291 484,465 -0.38 7,722 7,407 -4.08
2018-08-14 13F-HR STATE STREET CORP 6,033,070 5,537,623 -8.21 93,090 105,884 13.74
2018-07-17 13F-HR ESSEX INVESTMENT MANAGEMENT CO LLC 34,338 657
2018-08-09 13F-HR Sullivan, Bruyette, Speros & Blaney, Inc. 39,150 39,150 0.00 604 749 24.01
2017-02-10 13F-HR BlackRock Japan Co. Ltd 2,872 3,286 14.42 46 50 8.70
2018-08-14 13F-HR A.R.T. Advisors, LLC 13,493 39,993 196.40 208 764 267.31
2018-02-12 13F-HR Hutchin Hill Capital, LP 185,100 0 -100.00 2,919 0 -100.00
2018-08-14 13F-HR Jefferies Group LLC 0 35,478 0 678
2018-08-14 13F-HR BANK OF AMERICA CORP /DE/ Put 174,000 100,000 -42.53 2,685 1,912 -28.79
2018-08-14 13F-HR D. E. Shaw & Co., Inc. 172,370 114,809 -33.39 2,660 2,195 -17.48
2018-08-14 13F-HR Wellington Management Group LLP 19,131,830 19,263,267 0.69 295,205 368,312 24.76
2018-08-13 13F-HR PICTET ASSET MANAGEMENT LTD 3,217,089 1,996,776 -37.93 49,640 38,178 -23.09
2018-08-14 13F-HR FIFTH THIRD BANCORP 2,130 2,130 0.00 33 41 24.24
2018-08-14 13F-HR EcoR1 Capital, LLC Call 667,800 577,600 -13.51 10,305 11,044 7.17
2018-08-14 13F-HR Point72 Asset Management, L.P. 65,000 1,085,106 1,569.39 1,003 20,747 1,968.49
2018-07-18 13F-HR AMALGAMATED BANK 18,014 21,156 17.44 278 405 45.68
2017-02-10 13F-HR BlackRock Group LTD 107,385 127,111 18.37 1,706 1,943 13.89
2018-08-14 13F-HR Evercore Wealth Management, LLC 22,425 22,425 0.00 346 429 23.99
2018-08-06 13F-HR TEACHER RETIREMENT SYSTEM OF TEXAS 28,469 27,743 -2.55 439 530 20.73
2018-08-10 13F-HR OPPENHEIMER ASSET MANAGEMENT INC. 23,546 21,947 -6.79 363 420 15.70
2018-08-13 13F-HR FIRST REPUBLIC INVESTMENT MANAGEMENT, INC. 25,058 187,052 646.48 387 3,576 824.03
2018-08-10 13F-HR Shell Asset Management Co 13,833 13,094 -5.34 213 250 17.37
2018-08-14 13F-HR LPL Financial LLC 21,160 0 -100.00 326 0 -100.00
2018-08-07 13F-HR First Personal Financial Services 848 0 -100.00 13 0 -100.00
2018-08-14 13F-HR WOLVERINE ASSET MANAGEMENT LLC Put 224,700 300,100 33.56 3,467 5,737 65.47
2018-08-07 13F-HR Quantitative Systematic Strategies LLC 11,644 0 -100.00 180 0 -100.00
2018-07-23 13F-HR MIZUHO SECURITIES USA INC. 0 171,000 0 3,269,520
2018-08-08 13F-HR QUADRANT CAPITAL GROUP LLC 558 558 0.00 8 10 25.00
2018-08-10 13F-HR Summit Trail Advisors, Llc 11,875 0 -100.00 12 0 -100.00
2018-08-10 13F-HR VIRTUS ETF ADVISERS LLC 59,014 39,291 -33.42 911 751 -17.56
2018-08-13 13F-HR PRINCIPAL FINANCIAL GROUP INC 42,833 40,772 -4.81 661 779 17.85
2018-08-14 13F-HR UBS Group AG 154,957 220,036 42.00 2,392 4,207 75.88
2017-02-10 13F-HR BlackRock Institutional Trust Company, N.A. 3,335,616 3,548,966 6.40 52,970 54,264 2.44
2018-07-25 13F-HR PENN CAPITAL MANAGEMENT CO INC 849,299 900,856 6.07 13,221 17,363 31.33
2018-08-08 13F-HR SCHWAB CHARLES INVESTMENT MANAGEMENT INC 678,398 722,555 6.51 10,468 13,816 31.98
2018-08-14 13F-HR ROYAL BANK OF CANADA 6,251 3,663 -41.40 97 71 -26.80
2018-08-13 13F-HR ProShare Advisors LLC 80,511 76,217 -5.33 1,242 1,457 17.31
2018-08-03 13F-HR SEI INVESTMENTS CO 3,110 3,157 1.51 48 60 25.00
2018-08-10 13F-HR CHICAGO EQUITY PARTNERS LLC 220,750 244,275 10.66 3,406 4,671 37.14
2018-07-27 13F-HR PIEDMONT INVESTMENT ADVISORS LLC 2,405 46
2018-08-06 13F-HR STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 88,066 89,266 1.36 1,359 1,707 25.61

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RIGL: Rigel Pharmaceuticals Analysis and Research Report

2018-09-18 - Asif

Overview Rigel Pharmaceuticals is a biotechnology company dedicated to discovering, developing and providing novel small molecule drugs that significantly improve the lives of patients with immune and hematologic disorders, cancer and rare diseases. The company's pioneering research focuses on signaling pathways that are critical to disease mechanisms. The company's first FDA-approved product is TAVALISSE™ (fostamatinib disodium hexahydrate), an oral spleen tyrosine kinase (SYK) inhibitor, for the treatment of adult patients with chronic immune thrombocytopenia who have had an insufficient response to a previous treatment. The company's current clinical programs include Phase 2 studies of fostamatinib in autoimmune hemolytic anemia and IgA nephropathy, and a Phase 1 study for its IRAK program. In addition, Rigel Pharmaceuticals has product candidates in development with partners BerGenBio AS, Daiichi Sankyo, and Aclaris Therapeutics. Since inception, Rigel Pharmaceuticals h...

EKSO: Ekso Bionics Holdings Analysis and Research Report

2018-09-18 - Asif

Overview The company design, develop and sell exoskeleton technology to augment human strength, endurance and mobility. The company's exoskeleton technology serves multiple markets and can be used both by able-bodied users as well as by persons with physical disabilities. Ekso Bionics has sold, rented or leased devices that (a) enable individuals with neurological conditions affecting gait (stroke and spinal cord injury) to rehabilitate and to walk again and (b) allow industrial workers to perform heavy duty work for extended periods. Today, its medical exoskeleton, Ekso GT, is used as a rehabilitation tool to allow physicians and therapists to rehabilitate patients who have suffered a stroke or spinal cord injury. With its unique features designed specifically for hospitals and its proprietary SmartAssist software, Ekso GT allows for the early mobilization of patients, with high step count and high dosage treatments. The intent is to allow the patient’s central nervous syst...

AGRX: Agile Therapeutics Analysis and Research Report

2018-09-18 - Asif

Overview Agile Therapeutics is a forward-thinking women’s healthcare company dedicated to fulfilling the unmet health needs of today’s women. Twirla® and its other current potential product candidates are designed to provide women with contraceptive options that offer greater convenience and facilitate compliance. The company's lead product candidate, Twirla, also known as AG200-15, is a once-weekly prescription contraceptive patch that is at the end of Phase 3 clinical development. Since its inception in 1997, Agile Therapeutics has devoted substantial resources to developing Twirla, building its intellectual property portfolio, business planning, raising capital and providing general and administrative support for these operations. The company incurred research and development expenses of $14.4 million, $20.9 million and $25.6 million during the years ended December 31, 2017, 2016 and 2015, respectively. The company incurred research and development expenses of $2.4 milli...

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Your Daily Pharma Scoop: XBiotech Reports Positive Data, AstraZeneca's New Approval, Novartis' Positive MS Trial

2018-09-17 seekingalpha
XBiotech reported preliminary positive data from an open-label, dose escalation study of Phase 2 trial assessing its bermekimab candidate in moderate to severe atopic dermatitis (AD). On September 13, the share price climbed 28% pre-market on this apparently positive news. However, in spite of two subsequent spikes during the last two days, the share price has not yet fully recovered to its price range before the mid-September slide that wiped off ~50% of its share price between September 6 ($4. (54-0)

Ironwood Stock Up, Heart Candidate Gets Fast Track Status

2018-09-14 zacks
Ironwood Pharmaceuticals, Inc. (IRWD - Free Report) announced that the FDA has granted a fast track designation to its lead pipeline candidate, praliciguat, for the treatment of heart failure with preserved ejection fraction (HFpEF). (3-0)

Why Is Ironwood (IRWD) Up 0.9% Since Last Earnings Report?

2018-09-05 zacks
It has been about a month since the last earnings report for Ironwood Pharmaceuticals (IRWD - Free Report) . Shares have added about 0.9% in that time frame, underperforming the S&P 500. (5-0)

Your Daily Pharma Scoop: Audentes's New Designation, Esmya Rejected, Agilent Approved

2018-08-23 seekingalpha
Discussions: Audentes Therapeutics' (BOLD) AT132 receives FDA designation of a Regenerative Medicine Advanced Therapy (‘RMAT). The therapy is indicated for treatment of X-linked myotubular myopathy (‘XLMTM). RMAT is in many ways similar to the Breakthrough Therapy status and allows accelerated review of a drug along with more frequent interaction with the FDA during the development stage. The therapy has already acquired Rare Pediatric disease, Fast track and Orphan Drug Designation in the U. (24-1)

Ironwood's Linzess Gets Approval in Japan for New Indication

2018-08-22 zacks
Ironwood Pharmaceuticals, Inc. (IRWD - Free Report) and its Japanese partner Astellas Pharma announced that the label expansion application for its sole marketed drug, Linzess (linaclotide), to include chronic constipation has been approved in Japan. A dose of 0.25 mg in tablet formulation will be available in Japan. (6-0)

Synergy Pharmaceuticals Appears To Be Back On Track At Last

2018-08-20 seekingalpha
Synergy has faced the daunting task of commercializing constipation drug Trulance via a risky go-it-alone strategy; initial efforts were ruinously expensive and yielded anemic prescription growth. (3-2)

Ironwood Pharmaceuticals' Proposed Separation Should Offer A Favorable Outcome For Shareholders

2018-08-17 seekingalpha
Ironwood Pharmaceuticals is a commercial biotechnology company focused on the treatment of gastrointestinal diseases, abdominal pain, and gout. (10-1)

Ironwood Rides on Linzess' Progress, Stalls Lenisurad Drugs

2018-08-14 zacks
On Aug 13, we issued an updated research report on Ironwood Pharmaceuticals, Inc. (IRWD - Free Report) . This biopharmaceutical company, based in Cambridge, MA, is focused on the development and commercialization of treatments primarily addressing gastrointestinal (“GI”) diseases. The company’s sole marketed drug, Linzess, is indicated for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (“CIC”). (6-1)

Depomed's (DEPO) CEO Arthur Higgins on Q2 2018 Results - Earnings Call Transcript

2018-08-08 seekingalpha
Good morning, and welcome to the Depomed, Inc. Second Quarter 2018 Financial Results Call. My name is Louis, and I will be facilitating the audio portion of today’s interactive broadcast. [Operator Instructions] At this time, I would like to turn the show over to Mr. John Thomas, Senior Vice President for Investor Relations and Corporate Communications. Mr. Thomas, you may begin your conference. (5-2)

Ironwood (IRWD) Q2 Earnings & Revenues Miss, Shares Down

2018-08-07 zacks
Ironwood Pharmaceuticals, Inc. (IRWD - Free Report) reported second-quarter 2018 adjusted loss of 28 cents per share, wider than the Zacks Consensus Estimate of a loss of 19 cents and in line with the year-ago period. (6-0)

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