InvestorSabby Management, LLC
ManagerHal David Mintz
Insider ProfileSABBY MANAGEMENT, LLC
Portfolio Value $ 1,098,052,000
Current Positions161
Opened Positions5
Closed Positions65


Latest Holdings, Performance, AUM (from 13F, 13D)

Sabby Management, LLC has disclosed 161 total holdings in their latest SEC filings. Portfolio manager(s) are listed as Hal David Mintz. Most recent portfolio value is calculated to be $ 1,098,052,000 USD. Actual Assets Under Management (AUM) is this value plus cash (which is not disclosed). Sabby Management, LLC's top holdings are Bristol-Myers Squibb Co. (OTC:BMYMP) , Merck & Co., Inc. (NYSE:MRK) , bluebird bio, Inc. (NASDAQ:BLUE) , Bristol-Myers Squibb Co. (NYSE:BMY) , and AstraZeneca Plc (NYSE:AZN) . Sabby Management, LLC's new positions include Odonate Therapeutics, Inc. (NASDAQ:ODT) , Spark Therapeutics, Inc. (NASDAQ:ONCE) , Capnia, Inc. (NASDAQ:CAPN) , Agenus Inc. (NASDAQ:AGEN) , and Aimmune Therapeutics, Inc. (NASDAQ:AIMT) . Sabby Management, LLC's top industries are "Oil And Gas Extraction" (sic 13) , "Construction Special Trade Contractors" (sic 17) , and "Electronic And Other Electrical Equipment And Components, Except Computer Equipment" (sic 36) .

All Sabby Management, LLC holdings are listed in the following tables. Data is sourced from 13D/13G, 13F, and N-Q filings. Green rows indicate new positions. Red rows indicate closed positions.

This is a list of 13D and 13G filings made since the last quarterly 13F report (if any). Click the link icon to see the full transaction history.

File DateFormSecurity Prev
Shares
Current
Shares
Change
(Percent)
Ownership
Change
(Percent)
2018‑04‑24 SC 13G HEB / Hemispherx BioPharma, Inc. 1,584,885 3,300,000 108.22 7.18 43.89
2018‑04‑11 SC 13G RXII / RXI Pharmaceuticals Corporation 435,675 377,652 -13.32 8.87 77.76
2018‑04‑09 SC 13G OGEN / Oragenics, Inc. 450,000 7.39
2018‑04‑09 SC 13G MNKD / MannKind Corp. 7,801,908 5.57
2018‑04‑04 SC 13G INPX / Inpixon 542,403 5.81
2018‑03‑29 SC 13G ZSAN / Zosano Pharma Corporation 600,000 5.01
2018‑03‑29 SC 13G CTXR / Citius Pharmaceuticals Inc. 648,728 6.08
2018‑03‑29 SC 13G APRI / Apricus Biosciences, Inc. 1,800,000 7.68
2018‑03‑22 SC 13G EBIO / Eleven Biotherapeutics, Inc. 348,893 3,187,251 813.53 7.40 413.89
2018‑03‑22 SC 13G RKDA / Arcadia Biosciences, Inc. 150,376 6.17
2018‑03‑22 SC 13G APHB / Ampliphi Biosciences Corp. 473,997 1,280,910 170.24 7.78 55.91
2018‑03‑13 SC 13G CANF / Can-Fite Biopharma Ltd. 1,380,878 3,333,336 141.39 8.34 67.13
2018‑03‑12 SC 13G ROSG / Rosetta Genomics, Ltd. 674,576 351,372 -47.91 5.93 56.88
2018‑03‑08 SC 13G SCON / Superconductor Technologies, Inc. 536,887 1,190,000 121.65 9.97 99.80
2018‑02‑23 SC 13G NAOV / NanoVibronix, Inc. 276,687 7.33
2018‑02‑21 SC 13G MBRX / Moleculin Biotech, Inc. 0 1,502,350 5.83
2018‑02‑16 SC 13G OPGN / OpGen, Inc. 267,499 5.17
2018‑02‑16 SC 13G BIOA / BioAmber Inc. 2,521,319 5,666,666 124.75 8.41 73.76
2018‑02‑01 SC 13G BIOC / Biocept, Inc. 962,265 3,333,333 246.40 5.24 91.24
2018‑02‑01 SC 13G APOP / Cellect Biotechnology Ltd. 7,272,720 5.59
2018‑01‑09 SC 13G/A CHEK / Check-Cap Ltd. 1,431,369 1,007,494 -29.61 5.23 -37.96
2018‑01‑09 SC 13G/A CRMD / CorMedix Inc. 5,133,332 3,344,568 -34.85 4.99 -42.31
2018‑01‑09 SC 13G/A NWBO / Northwest Biotherapeutics, Inc. 22,553,659 15,761,350 -30.12 4.99 -50.05
2018‑01‑09 SC 13G/A TROV / TrovaGene, Inc. 2,124,250 2,634,150 24.00 4.99 -12.46
2018‑01‑09 SC 13G/A CVM / CEL-SCI Corp. 875,000 658,995 -24.69 4.99 -32.57
2018‑01‑09 SC 13G/A RTTR / Ritter Pharmaceuticals, Inc. 4,900,000 2,470,375 -49.58 4.99 -49.80
2018‑01‑09 SC 13G/A SNES / SenesTech, Inc. 1,250,000 787,896 -36.97 4.99 -36.99
2018‑01‑09 SC 13G/A AXSM / Axsome Therapeutics, Inc. 1,408,000 1,269,911 -9.81 4.99 -9.60
2018‑01‑09 SC 13G/A VTGN / VistaGen Therapeutics, Inc. 2,000,000 2,115,873 5.79 9.68 5.79
2018‑01‑09 SC 13G/A SVRA / Savara Inc 3,047,019 487,479 -84.00 1.60 -83.98
2018‑01‑09 SC 13G/A CYTR / CytRx Corp. 11,400,000 1,148,883 -89.92 4.16 -48.45
2018‑01‑09 SC 13G/A ONTX / Onconova Therapeutics, Inc. 789,396 561,163 -28.91 5.21 -39.06
2018‑01‑09 SC 13G/A HTBX / Heat Biologics, Inc. 3,250,000 2,615,123 -19.53 6.29 -35.15
2018‑01‑09 SC 13G/A RNVA / Rennova Health, Inc. 1,389,445 563,403 -59.45 9.99 0.00
2018‑01‑09 SC 13G/A TNDM / Tandem Diabetes Care, Inc. 570,000 504,921 -11.42 4.99 -11.37
2018‑01‑09 SC 13G/A MYO / Myomo Inc. 580,000 380,000 -34.48 3.63 -34.48
2018‑01‑08 SC 13G/A AYTU / Aytu BioScience, Inc. 717,424 216,542 -69.82 4.42 -33.13
2018‑01‑08 SC 13G/A MTFB / Motif Bio plc ADRs 16,956,520 0 -100.00 0.00 -100.00
2018‑01‑08 SC 13G/A IDXG / Interpace Diagnostics Group, Inc. 210,000 1,339,766 537.98 4.99 -33.29
2018‑01‑08 SC 13G/A CHFS / CHF Solutions 98,442 89,770 -8.81 4.99 -26.73
2018‑01‑08 SC 13G/A GEVNW / Gevo, Inc. 1,487,544 1,088,347 -26.84 4.99 -50.05
2018‑01‑08 SC 13G/A MDGS / Medigus Ltd. 4,894,391 7,549,161 54.24 4.99 -50.05
2018‑01‑08 SC 13G/A GENE / Genetic Technologies Ltd. 1,070,333 0 -100.00 0.00 -100.00
2018‑01‑08 SC 13G/A HSGX / Histogenics Corporation 630,000 1,201,144 90.66 4.99 -50.00
2018‑01‑08 SC 13G/A SKLN / Skyline Medical Inc. 630,000 126,000 -80.00 2.01 -79.86
2018‑01‑08 SC 13G/A AMDA / Amedica Corporation 2,100,000 78,750 -96.25 2.61 -54.92
2018‑01‑08 SC 13G/A GALE / Galena Biopharma, Inc. 2,523,298 112,794 -95.53 7.40 5.11
2018‑01‑08 SC 13G/A SGLB / Sigma Labs, Inc. 250,000 235,461 -5.82 4.99 -8.94
2018‑01‑08 SC 13G/A ANTH / Anthera Pharmaceuticals, Inc. 4,501,055 691,099 -84.65 4.99 -10.57
2018‑01‑08 SC 13G/A DMPI / DelMar Pharmaceuticals, Inc. 769,228 1,077,914 40.13 4.99 -12.61
2018‑01‑05 SC 13G/A ONS / Oncobiologics, Inc. 2,355,536 2,550,520 8.28 9.99 0.00
2018‑01‑05 SC 13G/A APDN / Applied DNA Sciences, Inc. 2,109,601 1,502,592 -28.77 4.99 -37.70
2018‑01‑05 SC 13G/A XTLB / XTL Biopharmaceuticals Ltd. 724,134 133,332 -81.59 2.93 -44.51
2018‑01‑04 SC 13G/A RIBT / RiceBran Technologies 875,286 842,512 -3.74 4.99 -38.55
2018‑01‑04 SC 13G/A CYTX / Cytori Therapeutics, Inc. 1,651,835 1,028,634 -37.73 2.93 -63.65
2018‑01‑04 SC 13G/A ONCS / OncoSec Medical Incorporated 1,173,946 1,147,989 -2.21 3.23 -45.71
2018‑01‑04 SC 13G/A ACXA / Accurexa Inc. 652,336 3,214,506 392.77 4.99 -29.62
2018‑01‑04 SC 13G/A XON / Intrexon Corp. 48,754 0.04
2018‑01‑04 SC 13G/A NURO / NeuroMetrix, Inc. 531,295 234,317 -55.90 9.99 0.00
2018‑01‑04 SC 13G/A CLSN / Celsion Corp. 3,117,223 801,511 -74.29 4.99 -50.05
2018‑01‑04 SC 13G/A GOVX / GeoVax Labs, Inc. 5,518,000 8,307,476 50.55 9.99 0.00
2018‑01‑04 SC 13G/A ABIO / ARCA biopharma, Inc. 457,600 557,652 21.86 4.75 -6.13
2018‑01‑04 SC 13G/A CBLI / Cleveland BioLabs, Inc. 858,600 149,876 -82.54 1.33 -83.38
2018‑01‑04 SC 13G/A TENX / Tenax Therapeutics, Inc. 2,740,535 0 -100.00 0.00 -100.00
2018‑01‑04 SC 13G/A CLRB / Cellectar Biosciences, Inc. 663,045 127,276 -80.80 0.80 -88.37
2018‑01‑04 SC 13G/A CRXM / Taxus Cardium Pharmaceuticals Group, Inc. 1,370,982 1,435,917 4.74 9.99 0.00
2018‑01‑03 SC 13G/A ARNI / Arno Therapeutics, Inc. 4,930,040 1,322,427 -73.18 2.68 -73.17
2018‑01‑02 SC 13D MELA / MELA Sciences, Inc 1,074,705 407,201 -62.11 9.99 0.00

This form was filed on February 15, 2018. Click the link icon to see the full transaction history.

Reporting Period Form Security Opt Imputed
Share Price
Prev
Shares
Current
Shares
Change
(Percent)
Prev Value
($1000)
Current Value
($1000)
Change
(Percent)
2017-12-31 13F-HR/A AVEO / AVEO Pharmaceuticals, Inc. Call 278.69 122 34
2017-12-31 13F-HR/A VICL / Vical Inc. 1.83 275,090 503
2017-12-31 13F-HR/A CAPN / Capnia, Inc. 1.80 915,100 1,647
2017-12-31 13F-HR/A AIMT / Aimmune Therapeutics, Inc. Put 3,783.78 222 840
2017-12-31 13F-HR/A LPTX / LEAP THERAPEUTICS, INC. 6.25 89,350 558
2017-12-31 13F-HR/A ODT / Odonate Therapeutics, Inc. 25.00 825,451 20,636
2017-12-31 13F-HR/A ACHN / Achillion Pharmaceuticals, Inc. Put 287.36 0 174 0 50
2017-12-31 13F-HR/A AXON / Axovant Sciences Ltd. 5.27 642,557 115,462 -82.03 4,421 608 -86.25
2017-12-31 13F-HR/A ESPR / Esperion Therapeutics, Inc. 65.84 83,357 142,185 70.57 4,178 9,361 124.05
2017-12-31 13F-HR/A IMMUTEP LTD / ADR (45257L108) 1.58 21,500 34
2017-12-31 13F-HR/A INSPIREMD INC / *W (45779A135) 0.02 2,003,848 40
2017-12-31 13F-HR/A ISHARES RUSSELL 2000 / ETF (464287905) Call 15,245.90 4,205 64,109
2017-12-31 13F-HR/A RGNX / REGENXBIO Inc. Call 3,320.99 78 81 3.85 257 269 4.67
2017-12-31 13F-HR/A SPDR S&P 500 / TR (78462F903) Call 17,852.67 3,000 53,558
2017-12-31 13F-HR/A SRPT / Sarepta Therapeutics, Inc. Call 5,564.00 7,263 9,023 24.23 32,945 50,204 52.39
2017-12-31 13F-HR/A SPHS / Sophiris Bio, Inc. 2.27 333,641 55,907 -83.24 716 127 -82.26
2017-12-31 13F-HR/A ACHN / Achillion Pharmaceuticals, Inc. Call 288.31 992 992 0.00 445 286 -35.73
2017-12-31 13F-HR/A IONS / Ionis Pharmaceuticals, Inc. Call 5,030.09 1,423 1,429 0.42 7,215 7,188 -0.37
2017-12-31 13F-HR/A DMPI / DelMar Pharmaceuticals, Inc. 2,121,202 0 -100.00 1,782 0 -100.00
2017-12-31 13F-HR/A TROV / TrovaGene, Inc. 1,689,778 0 -100.00 1,234 0 -100.00
2017-12-31 13F-HR/A AXON / Axovant Sciences Ltd. Call 527.03 1,270 2,146 68.98 874 1,131 29.41
2017-12-31 13F-HR/A APDNW / Applied DNA Sciences, Inc., Warrants 0.38 857,768 642,289 -25.12 575 244 -57.57
2017-12-31 13F-HR/A OREX / Orexigen Therapeutics, Inc. Put 197 0 -100.00 42 0 -100.00
2017-12-31 13F-HR/A OTIC / Otonomy, Inc. Call 275 0 -100.00 89 0 -100.00
2017-12-31 13F-HR/A RIBT / RiceBran Technologies 442,033 0 -100.00 575 0 -100.00
2017-12-31 13F-HR/A EYEG / Eyegate Pharmaceuticals Inc. 46,378 0 -100.00 54 0 -100.00
2017-12-31 13F-HR/A CRMD / CorMedix Inc. 648,955 0 -100.00 337 0 -100.00
2017-12-31 13F-HR/A UTHR / United Therapeutics Corp. Call 542 0 -100.00 6,352 0 -100.00
2017-12-31 13F-HR/A ATRS / Antares Pharma, Inc. Call 1,016 0 -100.00 329 0 -100.00
2017-12-31 13F-HR/A APHB / Ampliphi Biosciences Corp. 149,248 0 -100.00 136 0 -100.00
2017-12-31 13F-HR/A MDCO / Medicines Company Call 66 0 -100.00 244 0 -100.00
2017-12-31 13F-HR/A GEVNW / Gevo, Inc. 224,810 0 -100.00 140 0 -100.00
2017-12-31 13F-HR/A OHRP / Ohr Pharmaceutical, Inc. 152,127 0 -100.00 110 0 -100.00
2017-12-31 13F-HR/A VXZ / iPath® S&P 500 VIX Mid-Term Futures ETN 26,500 0 -100.00 551 0 -100.00
2017-12-31 13F-HR/A CYTR / CytRx Corp. Put 100 0 -100.00 4 0 -100.00
2017-12-31 13F-HR/A ATNM / Actinium Pharmaceuticals, Inc. 2,434,103 0 -100.00 1,400 0 -100.00
2017-12-31 13F-HR/A AEZS / AEterna Zentaris Inc. Put 174.24 0 264 0 46
2017-12-31 13F-HR/A AZN / AstraZeneca Plc Call 3,470.03 4,489 14,946 232.95 15,209 51,863 241.00
2017-12-31 13F-HR/A AZN / AstraZeneca Plc Put 3,469.98 2,043 7,511 267.65 6,922 26,063 276.52
2017-12-31 13F-HR/A ADVM / Adverum Biotechnologies, Inc. 3.50 0 300,000 0 1,050
2017-12-31 13F-HR/A ALXN / Alexion Pharmaceuticals, Inc. Call 11,959.51 0 247 0 2,954
2017-12-31 13F-HR/A ALXN / Alexion Pharmaceuticals, Inc. Put 11,958.33 0 96 0 1,148
2017-12-31 13F-HR/A ABIO / ARCA biopharma, Inc. 1.38 100,000 100,000 0.00 110 138 25.45
2017-12-31 13F-HR/A ALNY / Alnylam Pharmaceuticals, Inc. 127.06 0 19,250 0 2,446
2017-12-31 13F-HR/A ALNY / Alnylam Pharmaceuticals, Inc. Call 12,704.57 4,680 941 -79.89 54,985 11,955 -78.26
2017-12-31 13F-HR/A ALNY / Alnylam Pharmaceuticals, Inc. Put 12,704.93 3,165 1,603 -49.35 37,186 20,366 -45.23
2017-12-31 13F-HR/A FOLD / Amicus Therapeutics, Inc. Call 1,439.01 4,138 10,371 150.63 6,240 14,924 139.17
2017-12-31 13F-HR/A FOLD / Amicus Therapeutics, Inc. Put 1,439.00 500 2,000 300.00 754 2,878 281.70
2017-12-31 13F-HR/A AMRN / Amarin Corp. Plc Call 401.16 12,650 2,418 -80.89 4,428 970 -78.09
2017-12-31 13F-HR/A ALKS / Alkermes plc Call 5,472.80 0 1,599 0 8,751
2017-12-31 13F-HR/A ALKS / Alkermes plc Put 5,474.36 0 234 0 1,281
2017-12-31 13F-HR/A APDN / Applied DNA Sciences, Inc. 1.59 0 932,350 0 1,482
2017-12-31 13F-HR/A ADXS / Advaxis, Inc. Call 285.19 270 270 0.00 113 77 -31.86
2017-12-31 13F-HR/A ESPR / Esperion Therapeutics, Inc. Call 6,582.61 0 115 0 757
2017-12-31 13F-HR/A EGLT / Egalet Corporation 1.00 721,050 73,792 -89.77 923 74 -91.98
2017-12-31 13F-HR/A BLUE / bluebird bio, Inc. Call 17,810.12 3,931 4,250 8.11 53,992 75,693 40.19
2017-12-31 13F-HR/A BLUE / bluebird bio, Inc. Put 17,810.31 565 485 -14.16 7,760 8,638 11.31
2017-12-31 13F-HR/A AXON / Axovant Sciences Ltd. Put 527.06 7,679 1,848 -75.93 5,283 974 -81.56
2017-12-31 13F-HR/A DERM / Dermira, Inc. 27.81 0 45,304 0 1,260
2017-12-31 13F-HR/A DERM / Dermira, Inc. Put 2,780.68 0 766 0 2,130
2017-12-31 13F-HR/A BIIB / Biogen Inc. Put 3,821.74 0 230 0 879
2017-12-31 13F-HR/A BMY / Bristol-Myers Squibb Co. 61.28 982,955 931,807 -5.20 62,654 57,101 -8.86
2017-12-31 13F-HR/A CPST / Capstone Turbine Corp. 0.77 0 983,787 0 758
2017-12-31 13F-HR/A CLDN / Celladon Corporation 13.96 92,500 49,000 -47.03 1,018 684 -32.81
2017-12-31 13F-HR/A BMYMP / Bristol-Myers Squibb Co. Call 6,128.05 4,230 4,225 -0.12 26,962 25,891 -3.97
2017-12-31 13F-HR/A BNTCW / Benitec Biopharma Ltd 0.40 90,193 90,193 0.00 27 36 33.33
2017-12-31 13F-HR/A BPTH / Bio-Path Holdings, Inc. 0.20 0 1,833,449 0 371
2017-12-31 13F-HR/A BIOC / Biocept, Inc. 0.69 0 962,265 0 668
2017-12-31 13F-HR/A CI / Cigna Corp. Call 20,308.96 670 670 0.00 12,525 13,607 8.64
2017-12-31 13F-HR/A CFRX / ContraFect Corporation 1.02 119,156 34,333 -71.19 132 35 -73.48
2017-12-31 13F-HR/A BIOA / BioAmber Inc. 0.42 3,180,973 21,319 -99.33 1,559 9 -99.42
2017-12-31 13F-HR/A CHEK / Check-Cap Ltd. 0.87 1,184,917 1,007,494 -14.97 2,121 876 -58.70
2017-12-31 13F-HR/A BPMX / BioPharmX Corporation 0.11 0 6,713,756 0 740
2017-12-31 13F-HR/A IMUC.WS / ImmunoCellular Therapeutics, Ltd., Warrants 0.04 420,103 392,702 -6.52 8 16 100.00
2017-12-31 13F-HR/A INCY / Incyte Corp. Call 9,471.80 382 532 39.27 4,459 5,039 13.01
2017-12-31 13F-HR/A INCY / Incyte Corp. Put 9,471.04 184 1,036 463.04 2,148 9,812 356.80
2017-12-31 13F-HR/A NSPR / InspireMD, Inc. 0.03 4,321,909 1,193,470 -72.39 555 36 -93.51
2017-12-31 13F-HR/A NSPR / InspireMD, Inc. 0.13 1,194,322 4,321,909 261.87 41 555 1,253.66
2017-12-31 13F-HR/A ICPT / Intercept Pharmaceuticals, Inc. Call 5,841.16 100 447 347.00 580 2,611 350.17
2017-12-31 13F-HR/A GWPH / GW Pharmaceuticals Plc. Put 13,206.80 1,149 353 -69.28 11,661 4,662 -60.02
2017-12-31 13F-HR/A GILD / Gilead Sciences, Inc. Call 7,163.00 454 454 0.00 3,678 3,252 -11.58
2017-12-31 13F-HR/A HALO / Halozyme Therapeutics, Inc. Call 2,026.06 13,037 4,950 -62.03 22,645 10,029 -55.71
2017-12-31 13F-HR/A HTBX / Heat Biologics, Inc. 0.38 1,712,481 2,615,123 52.71 1,118 1,001 -10.47
2017-12-31 13F-HR/A GALE / Galena Biopharma, Inc. Call 26.18 6,084 7,602 24.95 215 199 -7.44
2017-12-31 13F-HR/A HSGX / Histogenics Corporation 2.05 481,667 955,060 98.28 954 1,958 105.24
2017-12-31 13F-HR/A FGEN / FibroGen, Inc. Call 4,741.82 1,384 275 -80.13 7,446 1,304 -82.49
2017-12-31 13F-HR/A IDRA / Idera Pharmaceuticals, Inc. 2.11 155,027 307,987 98.67 346 650 87.86
2017-12-31 13F-HR/A IPCI / Intellipharmaceutics International Inc. 0.80 0 1,083,637 0 867
2017-12-31 13F-HR/A JAGUAR HEALTH INC / (47010C201) 0.14 1,045,741 142
2017-12-31 13F-HR/A KAZIA THERAPEUTICS LTD / ADR (48669G105) 0.00 366,668 0
2017-12-31 13F-HR/A MNKD / MannKind Corp. 2.32 0 1,446,900 0 3,357
2017-12-31 13F-HR/A MNKD / MannKind Corp. Call 232.76 1,727 116 -93.28 375 27 -92.80
2017-12-31 13F-HR/A MNKD / MannKind Corp. Put 231.97 6,048 8,169 35.07 1,312 1,895 44.44
2017-12-31 13F-HR/A IONS / Ionis Pharmaceuticals, Inc. Put 5,030.08 1,612 1,230 -23.70 8,173 6,187 -24.30
2017-12-31 13F-HR/A MRK / Merck & Co., Inc. Call 5,626.99 44,139 18,222 -58.72 282,622 102,535 -63.72
2017-12-31 13F-HR/A MDGS / Medigus Ltd. 1.30 258,095 36,943 -85.69 578 48 -91.70
2017-12-31 13F-HR/A JUNO / Juno Therapeutics, Inc. Call 4,571.10 0 3,003 0 13,727
2017-12-31 13F-HR/A NKTR / Nektar Therapeutics 59.70 0 20,000 0 1,194
2017-12-31 13F-HR/A NKTR / Nektar Therapeutics Call 5,971.27 0 557 0 3,326
2017-12-31 13F-HR/A IDXG / Interpace Diagnostics Group, Inc. 1.02 0 1,319,290 0 1,346
2017-12-31 13F-HR/A ONS / Oncobiologics, Inc. 1.30 2,383,971 2,079,367 -12.78 3,266 2,703 -17.24
2017-12-31 13F-HR/A NURO / NeuroMetrix, Inc. 1.72 93,561 180,039 92.43 190 310 63.16
2017-12-31 13F-HR/A MBOT / Microbot Medical Inc 1.02 1,251,398 1,250,000 -0.11 1,464 1,275 -12.91
2017-12-31 13F-HR/A ONSIW / Oncobiologics, Inc. Series A Warrant Expiring 2/18/2018 0.03 158,295 89,644 -43.37 18 3 -83.33
2017-12-31 13F-HR/A PRQR / ProQR Therapeutics N.V. 3.23 0 347,245 0 1,120
2017-12-31 13F-HR/A RDUS / Radius Health, Inc. Call 3,177.08 0 1,536 0 4,880
2017-12-31 13F-HR/A RTTR / Ritter Pharmaceuticals, Inc. 0.33 4,657,800 357,781 -92.32 1,630 118 -92.76
2017-12-31 13F-HR/A PRTA / Prothena Corp plc 37.48 0 24,730 0 927
2017-12-31 13F-HR/A PRTA / Prothena Corp plc Call 3,750.00 999 240 -75.98 6,471 900 -86.09
2017-12-31 13F-HR/A PRTA / Prothena Corp plc Put 3,749.42 0 431 0 1,616
2017-12-31 13F-HR/A 74979C113 / RXI Pharmaceuticals Corporation, Warrants 0.13 2,100,797 2,100,797 0.00 355 273 -23.10
2017-12-31 13F-HR/A ONTX / Onconova Therapeutics, Inc. 1.50 840,960 561,163 -33.27 1,438 842 -41.45
2017-12-31 13F-HR/A RDHL / Redhill Biopharma Ltd 5.16 0 21,322 0 110
2017-12-31 13F-HR/A ONSIZ / Oncobiologics, Inc. Series B Warrant Expiring 5/18 0.02 260,018 199,193 -23.39 13 4 -69.23
2017-12-31 13F-HR/A PTI / Proteostasis Therapeutics, Inc. 5.83 150,151 60,000 -60.04 315 350 11.11
2017-12-31 13F-HR/A ONTXW / Onconova Therapeutics, Inc. Warrants 0.35 645,350 643,244 -0.33 252 225 -10.71
2017-12-31 13F-HR/A SAGE / Sage Therapeutics, Inc. Call 16,471.43 702 350 -50.14 4,373 5,765 31.83
2017-12-31 13F-HR/A SAGE / Sage Therapeutics, Inc. Put 16,471.04 0 259 0 4,266
2017-12-31 13F-HR/A SGMO / Sangamo BioSciences, Inc. Call 1,640.07 3,984 6,040 51.61 5,976 9,906 65.76
2017-12-31 13F-HR/A SGMO / Sangamo BioSciences, Inc. Put 1,639.93 575 2,730 374.78 863 4,477 418.77
2017-12-31 13F-HR/A OVAS / Ovascience Inc. 1.40 550,000 600,000 9.09 781 840 7.55
2017-12-31 13F-HR/A 68373L109 / OpGen, Inc. 0.19 1,659,500 1,129,867 -31.92 514 211 -58.95
2017-12-31 13F-HR/A ONCS / OncoSec Medical Incorporated 1.63 1,010,143 153,137 -84.84 968 249 -74.28
2017-12-31 13F-HR/A SPDR S&P BIOTECH / S&P BIOTECH (78464A970) Call 8,486.28 656 5,567
2017-12-31 13F-HR/A AGEN / Agenus Inc. Put 327.59 0 116 0 38
2017-12-31 13F-HR/A TRXC / TransEnterix, Inc. 1.93 0 708,097 0 1,367
2017-12-31 13F-HR/A VTGN / VistaGen Therapeutics, Inc. 1.11 0 2,115,873 0 2,352
2017-12-31 13F-HR/A TSRO / TESARO, Inc. 82.89 3,500 9,700 177.14 452 804 77.88
2017-12-31 13F-HR/A TSRO / TESARO, Inc. Call 8,282.35 100 85 -15.00 1,291 704 -45.47
2017-12-31 13F-HR/A TSRO / TESARO, Inc. Put 8,288.46 104 104 0.00 1,343 862 -35.82
2017-12-31 13F-HR/A VSAR / Versartis, Inc.. 2.20 707,300 993,100 40.41 1,733 2,185 26.08
2017-12-31 13F-HR/A VTVT / vTv Therapeutics Inc 6.00 60,897 44,500 -26.93 364 267 -26.65
2017-12-31 13F-HR/A SNSS / Sunesis Pharmaceuticals, Inc. 3.69 243,638 125,000 -48.69 473 461 -2.54
2017-12-31 13F-HR/A SNSS / Sunesis Pharmaceuticals, Inc. Call 369.49 0 885 0 327
2017-12-31 13F-HR/A SGYP / Synergy Pharmaceuticals, Inc. Call 222.96 0 4,243 0 946
2017-12-31 13F-HR/A ZGNX / Zogenix, Inc. Call 4,004.85 4,865 3,090 -36.49 17,052 12,375 -27.43
2017-12-31 13F-HR/A ZGNX / Zogenix, Inc. Put 4,005.39 1,275 1,114 -12.63 4,469 4,462 -0.16
2017-12-31 13F-HR/A VRTX / Vertex Pharmaceuticals Inc. Call 14,985.85 2,865 919 -67.92 43,559 13,772 -68.38
2017-12-31 13F-HR/A SSKN / Strata Skin Sciences, Inc. 1.24 211,695 335,105 58.30 375 416 10.93
2017-12-31 13F-HR/A XENE / Xenon Pharmaceuticals Inc. 2.83 307,600 329,400 7.09 907 931 2.65
2017-12-31 13F-HR/A SRPT / Sarepta Therapeutics, Inc. Put 5,563.86 518 1,472 184.17 2,350 8,190 248.51
2017-12-31 13F-HR/A ESPR / Esperion Therapeutics, Inc. Put 6,583.83 1,479 1,670 12.91 7,413 10,995 48.32
2017-12-31 13F-HR/A TRXC / TransEnterix, Inc. Put 193.11 3,426 3,050 -10.97 490 589 20.20
2017-12-31 13F-HR/A SPHS / Sophiris Bio, Inc. Put 225.45 112 275 145.54 24 62 158.33
2017-12-31 13F-HR/A ABBV / AbbVie Inc. 96.70 0 27,559 0 2,665
2017-12-31 13F-HR/A ONCE / Spark Therapeutics, Inc. 51.42 110,827 5,699
2017-12-31 13F-HR/A SNES / SenesTech, Inc. 0.72 436,863 315
2017-12-31 13F-HR/A MBLX / Metabolix, Inc. 1.77 215,250 381
2017-12-31 13F-HR/A CTXR / Citius Pharmaceuticals Inc. 3.90 210,131 820
2017-12-31 13F-HR/A ABBV / AbbVie Inc. Call 9,680.00 10,675 25 -99.77 94,858 242 -99.74
2017-12-31 13F-HR/A ABBV / AbbVie Inc. Put 9,671.39 0 776 0 7,505
2017-12-31 13F-HR/A AMAG / AMAG Pharmaceuticals, Inc. 13.25 80,108 118,864 48.38 1,478 1,575 6.56
2017-12-31 13F-HR/A AMAG / AMAG Pharmaceuticals, Inc. Call 1,325.50 254 553 117.72 469 733 56.29
2017-12-31 13F-HR/A AMAG / AMAG Pharmaceuticals, Inc. Put 1,324.92 3,004 1,822 -39.35 5,542 2,414 -56.44
2017-12-31 13F-HR/A ACHN / Achillion Pharmaceuticals, Inc. 2.87 0 16,705 0 48
2017-12-31 13F-HR/A MRK / Merck & Co., Inc. Put 5,627.07 4,179 2,652 -36.54 26,758 14,923 -44.23
2017-12-31 13F-HR/A CYTXW / Cytori Therapeutics, Inc. Warrants 0.01 1,237,952 1,028,634 -16.91 45 11 -75.56
2017-12-31 13F-HR/A GALE / Galena Biopharma, Inc. 0.26 2,702,228 2,623,610 -2.91 953 687 -27.91
2017-12-31 13F-HR/A BMYMP / Bristol-Myers Squibb Co. Put 6,127.99 33,069 34,682 4.88 210,782 212,531 0.83
2017-12-31 13F-HR/A GALT / Galectin Therapeutics Inc Put 334.22 337 1,131 235.61 72 378 425.00
2017-12-31 13F-HR/A EDAP / EDAP TMS S.A. Put 286.81 2,224 1,440 -35.25 663 413 -37.71
2017-12-31 13F-HR/A FCEL / FuelCell Energy, Inc. Put 44.50 239 1,236 417.15 42 55 30.95
2017-12-31 13F-HR/A VRTX / Vertex Pharmaceuticals Inc. Put 14,985.60 1,257 486 -61.34 19,111 7,283 -61.89
2017-12-31 13F-HR/A CLVS / Clovis Oncology, Inc. Call 6,805.97 1,112 67 -93.97 9,163 456 -95.02
2017-12-31 13F-HR/A OASM / Oasmia Pharmaceutical AB 0.89 19,000 19,000 0.00 20 17 -15.00
2017-12-31 13F-HR/A CHFS / CHF Solutions 3.47 367,893 52,490 -85.73 216 182 -15.74
2017-12-31 13F-HR/A SGLB / Sigma Labs, Inc. 0.48 70,000 382,868 446.95 132 184 39.39
2017-12-31 13F-HR/A BVXV / BiondVax Pharmaceuticals Ltd. 19,376 0 -100.00 139 0 -100.00
2017-12-31 13F-HR/A DBVT / DBV Technologies S.A. Put 1,784 0 -100.00 7,571 0 -100.00
2017-12-31 13F-HR/A DBVT / DBV Technologies S.A. Call 10,908 0 -100.00 46,294 0 -100.00
2017-12-31 13F-HR/A EKSO / Ekso Bionics Holdings, Inc. 702,364 0 -100.00 850 0 -100.00
2017-12-31 13F-HR/A FCEL / FuelCell Energy, Inc. 11,968 0 -100.00 21 0 -100.00
2017-12-31 13F-HR/A KRYS / Krystal Biotech, Inc. 53,558 0 -100.00 534 0 -100.00
2017-12-31 13F-HR/A ADMP / Adamis Pharmaceuticals Corp. 100,378 0 -100.00 524 0 -100.00
2017-12-31 13F-HR/A ATRS / Antares Pharma, Inc. Put 227 0 -100.00 74 0 -100.00
2017-12-31 13F-HR/A CEL SCI CORP. / (150837607) 587,822 0 -100.00 976 0
2017-12-31 13F-HR/A FPRX / Five Prime Therapeutics, Inc. Put 758 0 -100.00 3,101 0 -100.00
2017-12-31 13F-HR/A ISHARES RUSSELL 2000 / ETF (464287955) Put 5,980 0 -100.00 88,612 0
2017-12-31 13F-HR/A PTCT / PTC Therapeutics, Inc. Call 1,277 0 -100.00 2,555 0 -100.00
2017-12-31 13F-HR/A IMMU / Immunomedics, Inc. Call 1,322 0 -100.00 1,848 0 -100.00
2017-12-31 13F-HR/A SGEN / Seattle Genetics, Inc. Put 1,734 0 -100.00 9,435 0 -100.00
2017-12-31 13F-HR/A GWPH / GW Pharmaceuticals Plc. 28,517 0 -100.00 2,894 0 -100.00
2017-12-31 13F-HR/A INSM / Insmed, Inc. Call 1,375 0 -100.00 4,291 0 -100.00
2017-12-31 13F-HR/A INSM / Insmed, Inc. Put 1,851 0 -100.00 5,777 0 -100.00
2017-12-31 13F-HR/A ADXS / Advaxis, Inc. Put 414 0 -100.00 173 0 -100.00
2017-12-31 13F-HR/A GBT / Global Blood Therapeutics, Inc. Call 301 0 -100.00 935 0 -100.00
2017-12-31 13F-HR/A ANTH / Anthera Pharmaceuticals, Inc. 52,046 0 -100.00 75 0 -100.00
2017-12-31 13F-HR/A VSAR / Versartis, Inc.. Call 632 0 -100.00 155 0 -100.00
2017-12-31 13F-HR/A SRRA / Sierra Oncology 533,563 0 -100.00 827 0 -100.00
2017-12-31 13F-HR/A RNN / Rexahn Pharmaceuticals, Inc, 169,901 0 -100.00 411 0 -100.00
2017-12-31 13F-HR/A OREX / Orexigen Therapeutics, Inc. 19,700 0 -100.00 42 0 -100.00
2017-12-31 13F-HR/A CLSN / Celsion Corp. 67,403 0 -100.00 101 0 -100.00
2017-12-31 13F-HR/A KDMN / Kadmon Holdings, Inc. 525,695 0 -100.00 1,761 0 -100.00
2017-12-31 13F-HR/A NTLA / Intellia Therapeutics, Inc. 11,281 0 -100.00 280 0 -100.00
2017-12-31 13F-HR/A AERI / Aerie Pharmaceuticals, Inc. 4,726 0 -100.00 230 0 -100.00
2017-12-31 13F-HR/A AERI / Aerie Pharmaceuticals, Inc. Put 74 0 -100.00 360 0 -100.00
2017-12-31 13F-HR/A ROSG / Rosetta Genomics, Ltd. 141,741 0 -100.00 149 0 -100.00
2017-12-31 13F-HR/A SPDR S&P 500 ETF / TR (78462F953) Put 5,000 0 -100.00 125,615 0
2017-12-31 13F-HR/A KITE / Kite Pharma, Inc. Put 543 0 -100.00 9,764 0 -100.00
2017-12-31 13F-HR/A NLNK / NewLink Genetics Corp Call 1,000 0 -100.00 1,018 0 -100.00
2017-12-31 13F-HR/A NLNK / NewLink Genetics Corp Put 122 0 -100.00 124 0 -100.00
2017-12-31 13F-HR/A STML / Stemline Therapeutics, Inc. 43,749 0 -100.00 486 0 -100.00
2017-12-31 13F-HR/A STML / Stemline Therapeutics, Inc. Call 802 0 -100.00 890 0 -100.00
2017-12-31 13F-HR/A IDRA / Idera Pharmaceuticals, Inc. Call 416 0 -100.00 93 0 -100.00
2017-12-31 13F-HR/A CDTX / Cidara Therapeutics, Inc. 64,300 0 -100.00 521 0 -100.00
2017-12-31 13F-HR/A ADMP / Adamis Pharmaceuticals Corp. Put 574 0 -100.00 300 0 -100.00
2017-12-31 13F-HR/A SGEN / Seattle Genetics, Inc. 42,646 0 -100.00 2,320 0 -100.00
2017-12-31 13F-HR/A SGEN / Seattle Genetics, Inc. Call 542 0 -100.00 2,949 0 -100.00
2017-12-31 13F-HR/A CYTK / Cytokinetics, Inc. Call 3,398 0 -100.00 4,927 0 -100.00
2017-12-31 13F-HR/A CYTK / Cytokinetics, Inc. Put 237 0 -100.00 344 0 -100.00
2017-12-31 13F-HR/A ROKA / Roka Bioscience, Inc. 237,322 0 -100.00 173 0 -100.00
2017-12-31 13F-HR/A FLXN / Flexion Therapeutics, Inc. Call 341 0 -100.00 825 0 -100.00
2017-12-31 13F-HR/A FLXN / Flexion Therapeutics, Inc. Put 292 0 -100.00 706 0 -100.00
2017-12-31 13F-HR/A WVE / WAVE Life Sciences Ltd. 75,000 0 -100.00 1,631 0 -100.00
2017-12-31 13F-HR/A RNVA / Rennova Health, Inc. 466,880 0 -100.00 91 0 -100.00
2017-12-31 13F-HR/A ADXS / Advaxis, Inc. 37,634 0 -100.00 157 0 -100.00
2017-12-31 13F-HR/A IMMU / Immunomedics, Inc. Put 6.56 305 2
2017-12-31 13F-HR/A AEZS / AEterna Zentaris Inc. Call 239.13 138 33
2017-12-31 13F-HR/A NAOV / NanoVibronix, Inc. 4.68 101,949 477
2017-12-31 13F-HR/A TNDM / Tandem Diabetes Care, Inc. 2.36 27,487 65
2017-12-31 13F-HR/A AGEN / Agenus Inc. Call 325.87 2,860 932
2017-12-31 13F-HR/A AIMT / Aimmune Therapeutics, Inc. 37.84 5,629 213
2017-12-31 13F-HR/A AMRS / Amyris, Inc. Put 376.00 250 94
2017-12-31 13F-HR/A NBRV / Nabriva Therapeutics AG 6.00 10,000 60
2017-12-31 13F-HR/A FCSC / Fibrocell Science Inc. 0.65 1,128,588 733
2017-12-31 13F-HR/A ANTH / Anthera Pharmaceuticals, Inc. Put 165.65 658 109