InvestorBaker Brothers Advisors LP
ManagerJulian and Felix Baker
Insider ProfileBAKER BROS. ADVISORS LP
Portfolio Value $ 11,537,077,000
Current Positions116
Opened Positions5
Closed Positions5


Latest Holdings, Performance, AUM (from 13F, 13D)

Baker Brothers Advisors LP has disclosed 116 total holdings in their latest SEC filings. Portfolio manager(s) are listed as Julian and Felix Baker. Most recent portfolio value is calculated to be $ 11,537,077,000 USD. Actual Assets Under Management (AUM) is this value plus cash (which is not disclosed). Baker Brothers Advisors LP's top holdings are Incyte Corp. (NASDAQ:INCY) , Seattle Genetics, Inc. (NASDAQ:SGEN) , Alexion Pharmaceuticals, Inc. (NASDAQ:ALXN) , ACADIA Pharmaceuticals, Inc. (NASDAQ:ACAD) , and BioMarin Pharmaceutical, Inc. (NASDAQ:BMRN) . Baker Brothers Advisors LP's new positions include Ablynx NV (OTC:ABYLY) , Erytech Pharma (OTC:EYRYY) , Rhythm Pharmaceuticals, Inc. (NASDAQ:RYTM) , Novavax, Inc. Bond 3.75% Due 2/1/2023 (670002AB0) , and Acorda Therapeutics, Inc. Bond 1.750% 6/1 (00484MAA4) . Baker Brothers Advisors LP's top industries are "Construction Special Trade Contractors" (sic 17) , "Measuring, Analyzing, And Controlling Instruments; Photographic, Medical And Optical Goods; Watches And Clocks" (sic 38) , and "Health Services" (sic 80) .

All Baker Brothers Advisors LP holdings are listed in the following tables. Data is sourced from 13D/13G, 13F, and N-Q filings. Green rows indicate new positions. Red rows indicate closed positions.

This is a list of 13D and 13G filings made since the last quarterly 13F report (if any). Click the link icon to see the full transaction history.

File DateFormSecurity Prev
Shares
Current
Shares
Change
(Percent)
Ownership
Change
(Percent)
2018‑04‑10 SC 13G NVTA / Invitae Corp. 7,288,300 8,399,411 15.25 12.60 -16.56
2018‑03‑23 SC 13D/A DBVT / DBV Technologies S.A. 3,638,589 4,753,466 30.64 16.10 8.78
2018‑03‑12 SC 13D/A GHDX / Genomic Health, Inc. 14,091,043 14,092,863 0.01 40.40 -1.22
2018‑03‑06 SC 13D/A IDRA / Idera Pharmaceuticals, Inc. 18,619,136 38,956,461 109.23 18.00 81.82
2018‑02‑13 SC 13G AGLE / Aeglea BioTherapeutics, Inc. 1,137,872 6.80
2018‑02‑13 SC 13G ASND / Ascendis Pharma AS 2,618,818 7.10
2018‑02‑13 SC 13G CBAY / Cymabay Therapeutics Inc. 2,991,775 6.80
2018‑02‑13 SC 13G/A BCRX / BioCryst Pharmaceuticals, Inc. 11,062,403 14,080,631 27.28 14.30 -4.60
2018‑02‑13 SC 13G TNXP / Tonix Pharmaceuticals Holding Corp. 699,500 8.90
2018‑02‑13 SC 13G/A TRIL / Trillium Therapeutics Inc. 413,697 668,313 61.55 4.99 -10.89
2018‑02‑13 SC 13G/A SGMO / Sangamo BioSciences, Inc. 4,055,876 2,113,376 -47.89 2.50 -56.90
2018‑02‑13 SC 13G/A ADHD / Alcobra Ltd. 0 0.00
2018‑02‑13 SC 13G/A CPRX / Catalyst Pharmaceuticals, Inc. 5,102,153 5,852,153 14.70 5.70 -6.56
2018‑02‑13 SC 13G/A CERS / Cerus Corp. 13,073,139 9,765,073 -25.30 8.50 -32.54
2018‑02‑13 SC 13G/A AMRN / Amarin Corp. Plc 22,169,509 22,669,509 2.26 8.40 1.20
2018‑02‑13 SC 13G/A ACOR / Acorda Therapeutics, Inc. 3,301,791 205,966 -93.76 0.40 -94.44
2018‑02‑13 SC 13G/A CFRX / ContraFect Corporation 4,167,876 7,381,006 77.09 9.99 0.00
2018‑02‑13 SC 13G RTTR / Ritter Pharmaceuticals, Inc. 2,800,000 5.70
2018‑02‑13 SC 13G ABYLY / Ablynx NV 4,631,286 6.20
2018‑02‑13 SC 13G/A HRTX / Heron Therapeutics, Inc. 4,084,803 4,852,807 18.80 7.30 -26.93
2018‑02‑13 SC 13G/A VSAR / Versartis, Inc.. 1,920,845 1,426,310 -25.75 4.00 -27.27
2018‑02‑13 SC 13G RYTM / Rhythm Pharmaceuticals, Inc. 2,049,020 7.50
2018‑02‑13 SC 13G MDGN / Medgenics, Inc. 4,055,142 6.80
2018‑02‑05 SC 13D/A SGEN / Seattle Genetics, Inc. 45,972,508 49,818,661 8.37 31.70 -1.55
2018‑01‑22 SC 13D/A BGNE / BeiGene, Ltd. 130,374,760 155,484,836 19.26 22.40 -5.08
2018‑01‑10 SC 13G/A AKAO / Achaogen, Inc. 4,582,382 122,482 -97.33 0.30 -97.71

This form was filed on February 14, 2018. Click the link icon to see the full transaction history.

Reporting Period Form Security Opt Imputed
Share Price
Prev
Shares
Current
Shares
Change
(Percent)
Prev Value
($1000)
Current Value
($1000)
Change
(Percent)
2017-12-31 13F-HR THLD / Threshold Pharmaceuticals, Inc. 10.03 72,412 72,412 0.00 505 726 43.76
2017-12-31 13F-HR TTOO / T2 Biosystems, Inc. 4.12 100,000 100,000 0.00 420 412 -1.90
2017-12-31 13F-HR ALKS / Alkermes plc 54.73 150,251 150,251 0.00 7,639 8,223 7.64
2017-12-31 13F-HR NBRV / Nabriva Therapeutics AG 5.98 938,235 938,235 0.00 7,684 5,611 -26.98
2017-12-31 13F-HR 74365AAB7 / Protalix BioTherapeutics, Inc. Bonds 4.5% 9/15/18 2,576 2,576 0.00
2017-12-31 13F-HR EYRYY / Erytech Pharma 22.02 3,090,069 68,043
2017-12-31 13F-HR IFRX / InflaRx N.V. 20.95 200,000 4,190
2017-12-31 13F-HR NKTR / Nektar Therapeutics 59.72 171,934 10,268
2017-12-31 13F-HR RYTM / Rhythm Pharmaceuticals, Inc. 29.06 2,049,020 59,545
2017-12-31 13F-HR MDWD / MediWound Ltd. 4.45 226,000 226,000 0.00 1,209 1,006 -16.79
2017-12-31 13F-HR ABYLY / Ablynx NV 24.99 4,161,118 103,986
2017-12-31 13F-HR AMRN / Amarin Corp. Plc 4.01 22,669,509 22,669,509 0.00 79,343 90,905 14.57
2017-12-31 13F-HR DVAX / Dynavax Technologies Corp. 18.71 75,000 75,000 0.00 1,613 1,403 -13.02
2017-12-31 13F-HR VNDA / Vanda Pharmaceuticals, Inc. 15.20 423,884 423,884 0.00 7,588 6,443 -15.09
2017-12-31 13F-HR RIGL / Rigel Pharmaceuticals, Inc. 3.88 2,518,882 2,518,882 0.00 6,398 9,773 52.75
2017-12-31 13F-HR AAAP / Advanced Accelerator Applications S.A 81.61 2,243,262 55,125 -97.54 151,689 4,499 -97.03
2017-12-31 13F-HR 670002AB0 / Novavax, Inc. Bond 3.75% Due 2/1/2023 39,536 40,863 3.36
2017-12-31 13F-HR KPTI / Karyopharm Therapeutics Inc. 9.60 216,990 216,990 0.00 2,383 2,083 -12.59
2017-12-31 13F-HR 09061GAH4 / BioMarin Pharmaceutical, Inc. Bond 15,193 14,928 -1.74
2017-12-31 13F-HR OVID / Ovid Therapeutics Inc. 9.87 333,333 333,333 0.00 2,857 3,290 15.16
2017-12-31 13F-HR MYOK / MyoKardia, Inc. 42.10 355,264 355,264 0.00 15,223 14,957 -1.75
2017-12-31 13F-HR BMRN / BioMarin Pharmaceutical, Inc. 89.17 5,905,673 7,583,084 28.40 549,641 676,184 23.02
2017-12-31 13F-HR ACHN / Achillion Pharmaceuticals, Inc. 2.88 1,856,637 2,856,637 53.86 8,336 8,227 -1.31
2017-12-31 13F-HR RTTR / Ritter Pharmaceuticals, Inc. 0.33 2,800,000 2,800,000 0.00 980 922 -5.92
2017-12-31 13F-HR QURE / uniQure N.V. 19.59 0 482,557 0 9,453
2017-12-31 13F-HR SGEN / Seattle Genetics, Inc. 53.50 45,725,556 45,725,556 0.00 2,487,928 2,446,317 -1.67
2017-12-31 13F-HR GWPH / GW Pharmaceuticals Plc. 132.01 75,000 221,800 195.73 7,612 29,280 284.66
2017-12-31 13F-HR ABUS / Arbutus Biopharma Corporation 5.05 180,582 180,582 0.00 1,120 912 -18.57
2017-12-31 13F-HR NVTA / Invitae Corp. 9.08 7,288,300 7,288,300 0.00 68,292 66,178 -3.10
2017-12-31 13F-HR GLPG / Galapagos N.V. 93.76 259,894 259,894 0.00 26,444 24,368 -7.85
2017-12-31 13F-HR JNCE / Jounce Therapeutics, Inc. 12.75 100,000 100,000 0.00 1,558 1,275 -18.16
2017-12-31 13F-HR CCXI / ChemoCentryx, Inc. 5.95 49,064 49,064 0.00 364 292 -19.78
2017-12-31 13F-HR SELB / Selecta Biosciences, Inc. 9.81 289,809 283,716 -2.10 5,289 2,783 -47.38
2017-12-31 13F-HR SGMO / Sangamo BioSciences, Inc. 16.40 2,113,376 2,113,376 0.00 31,701 34,659 9.33
2017-12-31 13F-HR TTPH / Tetraphase Pharmaceuticals, Inc. 6.30 935,000 935,000 0.00 6,395 5,891 -7.88
2017-12-31 13F-HR PGNX / Progenics Pharmaceuticals, Inc. 5.95 3,150,808 3,150,808 0.00 23,190 18,747 -19.16
2017-12-31 13F-HR INSM / Insmed, Inc. 31.18 700,000 700,000 0.00 21,847 21,826 -0.10
2017-12-31 13F-HR GHDX / Genomic Health, Inc. 34.20 13,780,480 13,781,102 0.00 442,215 471,314 6.58
2017-12-31 13F-HR GLYC / GlycoMimetics, Inc. 16.79 563,312 563,312 0.00 7,881 9,458 20.01
2017-12-31 13F-HR CERS / Cerus Corp. 3.38 9,745,209 9,745,209 0.00 26,604 32,939 23.81
2017-12-31 13F-HR ANAB / AnaptysBio, Inc. 100.72 111,386 181,386 62.84 3,893 18,269 369.28
2017-12-31 13F-HR 00767EAB8 / Aegerion Pharmaceuticals, Inc. 2.0% Bond due 2019-08-15 7,576 7,566 -0.13
2017-12-31 13F-HR ACAD / ACADIA Pharmaceuticals, Inc. 30.11 25,819,768 27,228,338 5.46 972,631 819,845 -15.71
2017-12-31 13F-HR FOMX / Foamix Pharmaceuticals Ltd. 6.01 2,466,702 2,466,702 0.00 13,690 14,825 8.29
2017-12-31 13F-HR CLLS / Cellectis S.A. 29.16 50,000 50,000 0.00 1,423 1,458 2.46
2017-12-31 13F-HR BTX.WS / BioTime, Inc. Warrants exp. 2018-10-01 0.10 20,084 20,084 0.00 4 2 -50.00
2017-12-31 13F-HR AERI / Aerie Pharmaceuticals, Inc. 59.75 299,356 299,356 0.00 14,549 17,887 22.94
2017-12-31 13F-HR MDGN / Medgenics, Inc. 1.20 4,546,426 4,055,142 -10.81 5,728 4,866 -15.05
2017-12-31 13F-HR AGIO / Agios Pharmaceuticals, Inc. 57.17 128,666 128,666 0.00 8,588 7,356 -14.35
2017-12-31 13F-HR INCY / Incyte Corp. 94.71 34,230,323 34,230,523 0.00 3,996,048 3,241,973 -18.87
2017-12-31 13F-HR VSAR / Versartis, Inc.. 2.20 1,437,214 1,426,310 -0.76 3,521 3,138 -10.88
2017-12-31 13F-HR BLCM / Bellicum Pharmaceuticals, Inc. 8.41 5,032,313 5,032,313 0.00 58,123 42,322 -27.19
2017-12-31 13F-HR INFI / Infinity Pharmaceuticals, Inc. 2.03 580,400 580,400 0.00 772 1,178 52.59
2017-12-31 13F-HR NBIX / Neurocrine Biosciences, Inc. 77.59 616,682 1,004,624 62.91 37,790 77,949 106.27
2017-12-31 13F-HR ECYT / Endocyte, Inc. 4.28 0 1,087,323 0 4,654
2017-12-31 13F-HR BCRX / BioCryst Pharmaceuticals, Inc. 4.91 13,997,172 13,997,172 0.00 73,346 68,726 -6.30
2017-12-31 13F-HR RXDX / Ignyta, Inc. 26.70 1,299,199 1,384,266 6.55 16,045 36,960 130.35
2017-12-31 13F-HR CBAY / Cymabay Therapeutics Inc. 9.20 2,991,775 2,991,775 0.00 24,114 27,524 14.14
2017-12-31 13F-HR ACOR / Acorda Therapeutics, Inc. 21.45 519,500 205,966 -60.35 12,286 4,418 -64.04
2017-12-31 13F-HR XLRN / Acceleron Pharma Inc. 42.44 163,900 163,900 0.00 6,117 6,956 13.72
2017-12-31 13F-HR SNSS / Sunesis Pharmaceuticals, Inc. 3.69 741,665 741,665 0.00 1,439 2,737 90.20
2017-12-31 13F-HR STML / Stemline Therapeutics, Inc. 15.60 633,497 633,497 0.00 7,032 9,883 40.54
2017-12-31 13F-HR SYRS / Syros Pharmaceuticals, Inc. 9.73 574,835 574,835 0.00 8,462 5,593 -33.90
2017-12-31 13F-HR AKAO / Achaogen, Inc. 10.74 3,886,878 122,482 -96.85 61,996 1,315 -97.88
2017-12-31 13F-HR NLNK / NewLink Genetics Corp 8.11 1,007,273 1,007,273 0.00 10,254 8,169 -20.33
2017-12-31 13F-HR LJPC / La Jolla Pharmaceutical Co. 32.18 154,675 154,675 0.00 5,380 4,977 -7.49
2017-12-31 13F-HR AIMT / Aimmune Therapeutics, Inc. 37.82 673,908 673,908 0.00 16,706 25,487 52.56
2017-12-31 13F-HR BIOD / Biodel, Inc. 25.60 200,000 200,000 0.00 4,190 5,120 22.20
2017-12-31 13F-HR HRTX / Heron Therapeutics, Inc. 18.10 2,787,992 3,060,641 9.78 45,026 55,398 23.04
2017-12-31 13F-HR CRBP / Corbus Pharmaceuticals Holdings, Inc. 7.10 0 660,714 0 4,691
2017-12-31 13F-HR ALXN / Alexion Pharmaceuticals, Inc. 119.59 8,553,864 8,553,864 0.00 1,200,022 1,022,957 -14.76
2017-12-31 13F-HR ASMB / Assembly Biosciences, Inc. 45.25 250,000 322,727 29.09 8,730 14,603 67.27
2017-12-31 13F-HR ONCE / Spark Therapeutics, Inc. 51.42 1,384,130 1,384,130 0.00 123,409 71,172 -42.33
2017-12-31 13F-HR MRUS / Merus N.V. 19.40 1,160,014 1,160,014 0.00 23,049 22,504 -2.36
2017-12-31 13F-HR FPRX / Five Prime Therapeutics, Inc. 21.93 19,247 19,247 0.00 787 422 -46.38
2017-12-31 13F-HR 00484MAA4 / Acorda Therapeutics, Inc. Bond 1.750% 6/1 31,574 29,751 -5.77
2017-12-31 13F-HR FLGT / Fulgent Genetics, Inc. 4.38 125,000 125,000 0.00 599 548 -8.51
2017-12-31 13F-HR EPZM / Epizyme, Inc. 12.55 232,481 232,481 0.00 4,429 2,918 -34.12
2017-12-31 13F-HR ADMS / Adamas Pharmaceuticals, Inc. 33.89 172,630 172,630 0.00 3,655 5,850 60.05
2017-12-31 13F-HR AKTX / Akari Therapeutics Plc 4.33 496,901 696,901 40.25 3,051 3,018 -1.08
2017-12-31 13F-HR AQXP / Aquinox Pharmaceuticals, Inc. 11.76 10,934,154 10,934,154 0.00 155,156 128,586 -17.12
2017-12-31 13F-HR BLUE / bluebird bio, Inc. 178.10 241,441 200,000 -17.16 33,162 35,620 7.41
2017-12-31 13F-HR NVIV / InVivo Therapeutics Holdings Corp 0.77 400,000 331,393 -17.15 580 255 -56.03
2017-12-31 13F-HR BDSI / BioDelivery Sciences International, Inc. 2.95 210,021 210,021 0.00 620 620 0.00
2017-12-31 13F-HR ASND / Ascendis Pharma AS 40.06 2,348,840 2,618,818 11.49 85,145 104,910 23.21
2017-12-31 13F-HR DBVT / DBV Technologies S.A. 24.60 5,509,560 5,509,560 0.00 233,826 135,535 -42.04
2017-12-31 13F-HR LGND / Ligand Pharmaceuticals Incorporated 136.93 73,386 73,386 0.00 9,992 10,049 0.57
2017-12-31 13F-HR CPRX / Catalyst Pharmaceuticals, Inc. 3.91 5,102,153 5,852,153 14.70 12,857 22,882 77.97
2017-12-31 13F-HR AGLE / Aeglea BioTherapeutics, Inc. 5.41 1,137,872 1,137,872 0.00 5,609 6,156 9.75
2017-12-31 13F-HR TRVN / Trevena, Inc. 1.60 950,000 950,000 0.00 2,423 1,520 -37.27
2017-12-31 13F-HR AFMD / Affimed N.V. 1.30 400,000 400,000 0.00 900 520 -42.22
2017-12-31 13F-HR 45780VAB8 / Inotek Pharmaceuticals Corporation Bonds 5.75% 8/1/2021 3,904 4,009 2.69
2017-12-31 13F-HR CFRX / ContraFect Corporation 1.01 7,153,076 7,153,076 0.00 7,940 7,225 -9.01
2017-12-31 13F-HR AVXS / AveXis, Inc. 110.67 775,000 775,000 0.00 74,966 85,769 14.41
2017-12-31 13F-HR KRYS / Krystal Biotech, Inc. 10.52 200,000 200,000 0.00 1,994 2,104 5.52
2017-12-31 13F-HR EXEL / Exelixis, Inc. 30.40 2,082,012 1,506,499 -27.64 50,447 45,798 -9.22
2017-12-31 13F-HR NVAX / Novavax, Inc. 1.24 2,000,000 2,000,000 0.00 2,280 2,480 8.77
2017-12-31 13F-HR TNXP / Tonix Pharmaceuticals Holding Corp. 3.45 699,500 699,500 0.00 3,190 2,413 -24.36
2017-12-31 13F-HR TRIL / Trillium Therapeutics Inc. 7.25 413,697 409,323 -1.06 2,131 2,968 39.28
2017-12-31 13F-HR IMGN / Immunogen, Inc. 6.41 2,688,489 2,563,489 -4.65 20,567 16,432 -20.11
2017-12-31 13F-HR MRTX / Mirati Therapeutics, Inc. 18.25 2,269,198 2,549,461 12.35 26,549 46,528 75.25
2017-12-31 13F-HR ITCI / Intra-Cellular Therapies Inc. 14.48 609,166 609,166 0.00 9,613 8,821 -8.24
2017-12-31 13F-HR SAGE / Sage Therapeutics, Inc. 164.71 405,485 616,514 52.04 25,262 101,546 301.97
2017-12-31 13F-HR SNTA / Synta Pharmaceuticals, Inc. 91.79 57,762 615,684 965.90 2,598 56,514 2,075.29
2017-12-31 13F-HR IDRA / Idera Pharmaceuticals, Inc. 2.11 10,306,757 18,315,802 77.71 22,984 38,646 68.14
2017-12-31 13F-HR MGNX / MacroGenics, Inc. 19.00 363,676 363,676 0.00 6,721 6,910 2.81
2017-12-31 13F-HR PRTO / Proteon Therapeutics, Inc. 1.90 298,591 298,591 0.00 597 567 -5.03
2017-12-31 13F-HR ARRY / Array BioPharma, Inc. 12.80 5,213,528 5,656,196 8.49 64,126 72,399 12.90
2017-12-31 13F-HR ADAP / Adaptimmune Therapeutics plc 6.68 100,000 100,000 0.00 819 668 -18.44
2017-12-31 13F-HR HALO / Halozyme Therapeutics, Inc. 20.26 1,581,424 1,581,424 0.00 27,469 32,040 16.64
2017-12-31 13F-HR XNCR / Xencor, Inc. 21.92 872,072 872,072 0.00 19,988 19,116 -4.36
2017-12-31 13F-HR BGNE / BeiGene, Ltd. 97.72 3,898,431 3,849,231 -1.26 403,332 376,147 -6.74
2017-12-31 13F-HR TENX / Tenax Therapeutics, Inc. 0.49 348,374 348,374 0.00 126 171 35.71
2017-12-31 13F-HR CYCCP / Cyclacel Pharmaceuticals Inc., 6.00% Convertible Exchangeable Preferred Stock 6.94 13,253 13,253 0.00 98 92 -6.12
2017-12-31 13F-HR ABEO / Abeona Therapeutics Inc. 15.85 1,684,364 1,984,364 17.81 28,718 31,452 9.52
2017-12-31 13F-HR CMTA / Clementia Pharmaceuticals Inc. 18.98 250,000 250,000 0.00 4,223 4,745 12.36
2017-12-31 13F-HR IMDZ / Immune Design Corp. 3.90 148,937 148,937 0.00 1,541 581 -62.30
2017-12-31 13F-HR 09061GAE1 / BioMarin Pharmaceutical Inc. Bond 0.75% 10/15/2018 13,634 13,218 -3.05
2017-12-31 13F-HR NTLA / Intellia Therapeutics, Inc. 19.22 1,062,120 1,145,453 7.85 26,394 22,016 -16.59
2017-12-31 13F-HR RARX / Ra Pharmaceuticals, Inc. 8.50 177,952 177,952 0.00 2,598 1,513 -41.76
2017-12-31 13F-HR SBPH / Spring Bank Pharmaceuticals, Inc. 13.44 373,144 373,144 0.00 6,284 5,015 -20.19
2017-12-31 13F-HR ARGX / argenx SE ADS 63.14 100,000 961,754 861.75 2,261 60,725 2,585.76
2017-12-31 13F-HR NTRA / Natera, Inc. 8.99 228,676 228,676 0.00 2,948 2,056 -30.26
2017-12-31 13F-HR VYGR / Voyager Therapeutics, Inc 237,014 0 -100.00 4,880 0 -100.00
2017-12-31 13F-HR DMTX / Dimension Therapeutics, Inc. 1,251,881 0 -100.00 7,511 0 -100.00
2017-12-31 13F-HR LOXO / Loxo Oncology, Inc. 96,062 0 -100.00 8,849 0 -100.00
2017-12-31 13F-HR NDRM / NeuroDerm Ltd. 571,667 0 -100.00 22,238 0 -100.00
2017-12-31 13F-HR BPMX / BioPharmX Corporation 598,758 0 -100.00 171 0 -100.00