Current Holdings (from 13F, 13D)

InvestorBaker Brothers Advisors LP
ManagerJulian and Felix Baker
Insider ProfileBAKER BROS. ADVISORS LP
Portfolio Value$ 12,330,918,000
Current Positions113
Opened Positions5
Closed Positions9

Baker Brothers Advisors LP has disclosed 113 total holdings in their latest SEC filings. Portfolio manager(s) are listed as Julian and Felix Baker. Most recent portfolio value is calculated to be $ 12,330,918,000 USD. Actual Assets Under Management (AUM) is this value plus cash (which is not disclosed). Baker Brothers Advisors LP's top holdings are Incyte Corp. (NASDAQ:INCY) , Seattle Genetics, Inc. (NASDAQ:SGEN) , Alexion Pharmaceuticals, Inc. (NASDAQ:ALXN) , ACADIA Pharmaceuticals, Inc. (NASDAQ:ACAD) , and BioMarin Pharmaceutical, Inc. (NASDAQ:BMRN) . Baker Brothers Advisors LP's new positions include Novavax, Inc. Bond 3.75% Due 2/1/2023 (670002AB0) , Acorda Therapeutics, Inc. Bond 1.750% 6/1 (00484MAA4) , BioMarin Pharmaceutical, Inc. Bond (09061GAH4) , BioMarin Pharmaceutical Inc. Bond 0.75% 10/15/2018 (09061GAE1) , and Aegerion Pharmaceuticals, Inc. 2.0% Bond due 2019-08-15 (00767EAB8) . Baker Brothers Advisors LP's top industries are "Construction Special Trade Contractors" (sic 17) , "Measuring, Analyzing, And Controlling Instruments; Photographic, Medical And Optical Goods; Watches And Clocks" (sic 38) , and "Health Services" (sic 80) .


All Baker Brothers Advisors LP holdings are listed in the following table. This data is sourced from 13D/13G, and 13F filings. Green rows indicate new positions. Red rows indicate closed positions.

This is a list of 13D and 13G filings made since the last quarterly 13F report (if any). Click the link icon to see the full transaction history.

File DateFormSecurity Prev
Shares
Current
Shares
Change
(Percent)
Ownership
Change
(Percent)
2018‑01‑10 SC 13G/A AKAO / Achaogen, Inc. 4,582,382 122,482 -97.33 0.30 -97.71
2017‑11‑20 SC 13D/A MRTX / Mirati Therapeutics, Inc. 2,549,598 2,712,984 6.41 9.99 -20.71
2017‑11‑16 SC 13D EYRYY / Erytech Pharma 4,898,337 27.30
2017‑10‑30 SC 13D/A IDRA / Idera Pharmaceuticals, Inc. 10,487,314 18,619,136 77.54 9.90 37.50
2017‑10‑16 SC 13D/A ACAD / ACADIA Pharmaceuticals, Inc. 27,372,236 27,339,279 -0.12 22.10 0.00

This 13F was filed on November 14, 2017. Click the link icon to see the full transaction history.

Reporting PeriodFormSecurity Imputed
Share Price
Prev SharesCurrent SharesChange
(Percent)
Prev Value ($K)Current Value ($K)Change
(Percent)
2017‑09‑30 13F-HR SNTA / Synta Pharmaceuticals, Inc. 44.98 57,762 57,762 0.00 939 2,598 176.68
2017‑09‑30 13F-HR AMRN / Amarin Corp. Plc 3.50 22,669,509 22,669,509 0.00 91,358 79,343 -13.15
2017‑09‑30 13F-HR AAAP / Advanced Accelerator Applications S.A 67.62 2,221,706 2,243,262 0.97 86,735 151,689 74.89
2017‑09‑30 13F-HR CMTA / Clementia Pharmaceuticals Inc. 16.89 250,000 4,223
2017‑09‑30 13F-HR KRYS / Krystal Biotech, Inc. 9.97 200,000 1,994
2017‑09‑30 13F-HR 09061GAH4 / BioMarin Pharmaceutical, Inc. Bond 15,193
2017‑09‑30 13F-HR THLD / Threshold Pharmaceuticals, Inc. 6.97 72,412 505
2017‑09‑30 13F-HR TTOO / T2 Biosystems, Inc. 4.20 100,000 420
2017‑09‑30 13F-HR TTPH / Tetraphase Pharmaceuticals, Inc. 6.84 935,000 6,395
2017‑09‑30 13F-HR VYGR / Voyager Therapeutics, Inc 20.59 237,014 4,880
2017‑09‑30 13F-HR VNDA / Vanda Pharmaceuticals, Inc. 17.90 0 423,884 0 7,588
2017‑09‑30 13F-HR RIGL / Rigel Pharmaceuticals, Inc. 2.54 2,518,882 2,518,882 0.00 6,877 6,398 -6.97
2017‑09‑30 13F-HR 670002AB0 / Novavax, Inc. Bond 3.75% Due 2/1/2023 46,429 39,536 -14.85
2017‑09‑30 13F-HR DVAX / Dynavax Technologies Corp. 21.51 75,000 75,000 0.00 724 1,613 122.79
2017‑09‑30 13F-HR KPTI / Karyopharm Therapeutics Inc. 10.98 216,990 216,990 0.00 1,964 2,383 21.33
2017‑09‑30 13F-HR OVID / Ovid Therapeutics Inc. 8.57 333,333 333,333 0.00 3,497 2,857 -18.30
2017‑09‑30 13F-HR MYOK / MyoKardia, Inc. 42.85 100,000 355,264 255.26 1,310 15,223 1,062.06
2017‑09‑30 13F-HR BMRN / BioMarin Pharmaceutical, Inc. 93.07 5,905,673 5,905,673 0.00 536,353 549,641 2.48
2017‑09‑30 13F-HR ACHN / Achillion Pharmaceuticals, Inc. 4.49 1,856,637 1,856,637 0.00 8,522 8,336 -2.18
2017‑09‑30 13F-HR RTTR / Ritter Pharmaceuticals, Inc. 0.35 400,000 2,800,000 600.00 220 980 345.45
2017‑09‑30 13F-HR DMTX / Dimension Therapeutics, Inc. 6.00 1,251,881 1,251,881 0.00 1,815 7,511 313.83
2017‑09‑30 13F-HR GWPH / GW Pharmaceuticals Plc. 101.49 0 75,000 0 7,612
2017‑09‑30 13F-HR SGEN / Seattle Genetics, Inc. 54.41 45,725,556 45,725,556 0.00 2,365,840 2,487,928 5.16
2017‑09‑30 13F-HR ABUS / Arbutus Biopharma Corporation 6.20 180,582 180,582 0.00 650 1,120 72.31
2017‑09‑30 13F-HR NVTA / Invitae Corp. 9.37 7,288,300 7,288,300 0.00 69,676 68,292 -1.99
2017‑09‑30 13F-HR GLPG / Galapagos N.V. 101.75 259,894 259,894 0.00 19,887 26,444 32.97
2017‑09‑30 13F-HR JNCE / Jounce Therapeutics, Inc. 15.58 100,000 100,000 0.00 1,403 1,558 11.05
2017‑09‑30 13F-HR CCXI / ChemoCentryx, Inc. 7.42 49,064 49,064 0.00 459 364 -20.70
2017‑09‑30 13F-HR SELB / Selecta Biosciences, Inc. 18.25 289,809 289,809 0.00 5,756 5,289 -8.11
2017‑09‑30 13F-HR SGMO / Sangamo BioSciences, Inc. 15.00 4,113,376 2,113,376 -48.62 36,198 31,701 -12.42
2017‑09‑30 13F-HR PGNX / Progenics Pharmaceuticals, Inc. 7.36 3,150,808 3,150,808 0.00 21,394 23,190 8.39
2017‑09‑30 13F-HR INSM / Insmed, Inc. 31.21 400,000 700,000 75.00 6,864 21,847 218.28
2017‑09‑30 13F-HR GHDX / Genomic Health, Inc. 32.09 13,779,866 13,780,480 0.00 448,535 442,215 -1.41
2017‑09‑30 13F-HR GLYC / GlycoMimetics, Inc. 13.99 563,312 563,312 0.00 6,287 7,881 25.35
2017‑09‑30 13F-HR CERS / Cerus Corp. 2.73 10,241,943 9,745,209 -4.85 25,707 26,604 3.49
2017‑09‑30 13F-HR ANAB / AnaptysBio, Inc. 34.95 117,211 111,386 -4.97 2,805 3,893 38.79
2017‑09‑30 13F-HR 00767EAB8 / Aegerion Pharmaceuticals, Inc. 2.0% Bond due 2019-08-15 11,549 7,576 -34.40
2017‑09‑30 13F-HR ACAD / ACADIA Pharmaceuticals, Inc. 37.67 25,819,768 25,819,768 0.00 720,113 972,631 35.07
2017‑09‑30 13F-HR FOMX / Foamix Pharmaceuticals Ltd. 5.55 2,466,702 2,466,702 0.00 11,445 13,690 19.62
2017‑09‑30 13F-HR CLLS / Cellectis S.A. 28.46 50,000 50,000 0.00 1,291 1,423 10.22
2017‑09‑30 13F-HR BTX.WS / BioTime, Inc. Warrants exp. 2018-10-01 0.20 20,084 20,084 0.00 7 4 -42.86
2017‑09‑30 13F-HR AERI / Aerie Pharmaceuticals, Inc. 48.60 299,356 299,356 0.00 15,731 14,549 -7.51
2017‑09‑30 13F-HR MDGN / Medgenics, Inc. 1.26 1,618,089 4,546,426 180.98 2,152 5,728 166.17
2017‑09‑30 13F-HR AGIO / Agios Pharmaceuticals, Inc. 66.75 128,666 128,666 0.00 6,620 8,588 29.73
2017‑09‑30 13F-HR INCY / Incyte Corp. 116.74 34,130,161 34,230,323 0.29 4,297,329 3,996,048 -7.01
2017‑09‑30 13F-HR VSAR / Versartis, Inc.. 2.45 1,660,593 1,437,214 -13.45 28,977 3,521 -87.85
2017‑09‑30 13F-HR BLCM / Bellicum Pharmaceuticals, Inc. 11.55 5,032,313 5,032,313 0.00 58,777 58,123 -1.11
2017‑09‑30 13F-HR LOXO / Loxo Oncology, Inc. 92.12 138,312 96,062 -30.55 11,091 8,849 -20.21
2017‑09‑30 13F-HR INFI / Infinity Pharmaceuticals, Inc. 1.33 580,400 580,400 0.00 911 772 -15.26
2017‑09‑30 13F-HR NBIX / Neurocrine Biosciences, Inc. 61.28 616,682 616,682 0.00 28,367 37,790 33.22
2017‑09‑30 13F-HR BCRX / BioCryst Pharmaceuticals, Inc. 5.24 11,716,784 13,997,172 19.46 65,145 73,346 12.59
2017‑09‑30 13F-HR RXDX / Ignyta, Inc. 12.35 896,000 1,299,199 45.00 9,274 16,045 73.01
2017‑09‑30 13F-HR CBAY / Cymabay Therapeutics Inc. 8.06 1,291,775 2,991,775 131.60 7,441 24,114 224.07
2017‑09‑30 13F-HR ACOR / Acorda Therapeutics, Inc. 23.65 0 519,500 0 12,286
2017‑09‑30 13F-HR XLRN / Acceleron Pharma Inc. 37.32 28,765 163,900 469.79 874 6,117 599.89
2017‑09‑30 13F-HR SNSS / Sunesis Pharmaceuticals, Inc. 1.94 741,665 741,665 0.00 2,002 1,439 -28.12
2017‑09‑30 13F-HR STML / Stemline Therapeutics, Inc. 11.10 633,497 633,497 0.00 5,828 7,032 20.66
2017‑09‑30 13F-HR SYRS / Syros Pharmaceuticals, Inc. 14.72 574,835 574,835 0.00 9,249 8,462 -8.51
2017‑09‑30 13F-HR AKAO / Achaogen, Inc. 15.95 4,804,604 3,886,878 -19.10 104,404 61,996 -40.62
2017‑09‑30 13F-HR NLNK / NewLink Genetics Corp 10.18 500,000 1,007,273 101.45 3,675 10,254 179.02
2017‑09‑30 13F-HR LJPC / La Jolla Pharmaceutical Co. 34.78 504,732 154,675 -69.36 15,026 5,380 -64.20
2017‑09‑30 13F-HR AIMT / Aimmune Therapeutics, Inc. 24.79 673,908 673,908 0.00 13,856 16,706 20.57
2017‑09‑30 13F-HR HRTX / Heron Therapeutics, Inc. 16.15 2,783,569 2,787,992 0.16 38,552 45,026 16.79
2017‑09‑30 13F-HR ALXN / Alexion Pharmaceuticals, Inc. 140.29 8,553,864 8,553,864 0.00 1,040,749 1,200,022 15.30
2017‑09‑30 13F-HR ASMB / Assembly Biosciences, Inc. 34.92 250,000 250,000 0.00 5,163 8,730 69.09
2017‑09‑30 13F-HR ONCE / Spark Therapeutics, Inc. 89.16 1,318,341 1,384,130 4.99 78,758 123,409 56.69
2017‑09‑30 13F-HR MRUS / Merus N.V. 19.87 1,160,014 1,160,014 0.00 18,386 23,049 25.36
2017‑09‑30 13F-HR FPRX / Five Prime Therapeutics, Inc. 40.89 19,247 19,247 0.00 580 787 35.69
2017‑09‑30 13F-HR 00484MAA4 / Acorda Therapeutics, Inc. Bond 1.750% 6/1 29,985 31,574 5.30
2017‑09‑30 13F-HR FLGT / Fulgent Genetics, Inc. 4.79 125,000 125,000 0.00 799 599 -25.03
2017‑09‑30 13F-HR EPZM / Epizyme, Inc. 19.05 232,481 232,481 0.00 3,510 4,429 26.18
2017‑09‑30 13F-HR ADMS / Adamas Pharmaceuticals, Inc. 21.17 172,630 172,630 0.00 3,019 3,655 21.07
2017‑09‑30 13F-HR AKTX / Akari Therapeutics Plc 6.14 496,901 496,901 0.00 2,291 3,051 33.17
2017‑09‑30 13F-HR AQXP / Aquinox Pharmaceuticals, Inc. 14.19 10,934,154 10,934,154 0.00 153,844 155,156 0.85
2017‑09‑30 13F-HR MDWD / MediWound Ltd. 5.35 226,000 226,000 0.00 1,537 1,209 -21.34
2017‑09‑30 13F-HR BLUE / bluebird bio, Inc. 137.35 301,441 241,441 -19.90 31,666 33,162 4.72
2017‑09‑30 13F-HR NVIV / InVivo Therapeutics Holdings Corp 1.45 400,000 400,000 0.00 1,080 580 -46.30
2017‑09‑30 13F-HR BDSI / BioDelivery Sciences International, Inc. 2.95 210,021 210,021 0.00 588 620 5.44
2017‑09‑30 13F-HR ASND / Ascendis Pharma AS 36.25 1,751,463 2,348,840 34.11 48,621 85,145 75.12
2017‑09‑30 13F-HR DBVT / DBV Technologies S.A. 42.44 5,509,560 5,509,560 0.00 196,746 233,826 18.85
2017‑09‑30 13F-HR LGND / Ligand Pharmaceuticals Incorporated 136.16 73,386 73,386 0.00 8,909 9,992 12.16
2017‑09‑30 13F-HR CPRX / Catalyst Pharmaceuticals, Inc. 2.52 5,102,153 5,102,153 0.00 14,082 12,857 -8.70
2017‑09‑30 13F-HR AGLE / Aeglea BioTherapeutics, Inc. 4.93 1,137,872 1,137,872 0.00 4,381 5,609 28.03
2017‑09‑30 13F-HR TRVN / Trevena, Inc. 2.55 950,000 950,000 0.00 2,185 2,423 10.89
2017‑09‑30 13F-HR AFMD / Affimed N.V. 2.25 400,000 400,000 0.00 820 900 9.76
2017‑09‑30 13F-HR 45780VAB8 / Inotek Pharmaceuticals Corporation Bonds 5.75% 8/1/2021 2,978 3,904 31.09
2017‑09‑30 13F-HR BIOD / Biodel, Inc. 20.95 200,000 200,000 0.00 4,120 4,190 1.70
2017‑09‑30 13F-HR CFRX / ContraFect Corporation 1.11 4,045,876 7,153,076 76.80 5,867 7,940 35.33
2017‑09‑30 13F-HR AVXS / AveXis, Inc. 96.73 625,000 775,000 24.00 51,350 74,966 45.99
2017‑09‑30 13F-HR EXEL / Exelixis, Inc. 24.23 2,082,012 2,082,012 0.00 51,280 50,447 -1.62
2017‑09‑30 13F-HR NVAX / Novavax, Inc. 1.14 2,000,000 2,000,000 0.00 2,300 2,280 -0.87
2017‑09‑30 13F-HR TNXP / Tonix Pharmaceuticals Holding Corp. 4.56 510,922 699,500 36.91 2,212 3,190 44.21
2017‑09‑30 13F-HR TRIL / Trillium Therapeutics Inc. 5.15 413,697 413,697 0.00 1,820 2,131 17.09
2017‑09‑30 13F-HR IMGN / Immunogen, Inc. 7.65 3,015,353 2,688,489 -10.84 21,439 20,567 -4.07
2017‑09‑30 13F-HR MRTX / Mirati Therapeutics, Inc. 11.70 2,269,198 2,269,198 0.00 8,283 26,549 220.52
2017‑09‑30 13F-HR ITCI / Intra-Cellular Therapies Inc. 15.78 609,166 609,166 0.00 7,566 9,613 27.06
2017‑09‑30 13F-HR SAGE / Sage Therapeutics, Inc. 62.30 208,328 405,485 94.64 16,591 25,262 52.26
2017‑09‑30 13F-HR IDRA / Idera Pharmaceuticals, Inc. 2.23 10,294,970 10,306,757 0.11 17,707 22,984 29.80
2017‑09‑30 13F-HR MGNX / MacroGenics, Inc. 18.48 363,676 363,676 0.00 6,368 6,721 5.54
2017‑09‑30 13F-HR NDRM / NeuroDerm Ltd. 38.90 571,667 571,667 0.00 17,093 22,238 30.10
2017‑09‑30 13F-HR PRTO / Proteon Therapeutics, Inc. 2.00 298,591 298,591 0.00 455 597 31.21
2017‑09‑30 13F-HR ARRY / Array BioPharma, Inc. 12.30 1,585,913 5,213,528 228.74 13,274 64,126 383.09
2017‑09‑30 13F-HR ADAP / Adaptimmune Therapeutics plc 8.19 100,000 100,000 0.00 449 819 82.41
2017‑09‑30 13F-HR HALO / Halozyme Therapeutics, Inc. 17.37 1,581,424 1,581,424 0.00 20,274 27,469 35.49
2017‑09‑30 13F-HR XNCR / Xencor, Inc. 22.92 872,072 872,072 0.00 18,409 19,988 8.58
2017‑09‑30 13F-HR 04269XAA3 / Array BioPharma Inc. Bonds 3.0% 6/1/2020 4,066 5,410 33.05
2017‑09‑30 13F-HR BGNE / BeiGene, Ltd. 103.46 3,673,175 3,898,431 6.13 165,293 403,332 144.01
2017‑09‑30 13F-HR TENX / Tenax Therapeutics, Inc. 0.36 132,974 348,374 161.99 98 126 28.57
2017‑09‑30 13F-HR CYCCP / Cyclacel Pharmaceuticals Inc., 6.00% Convertible Exchangeable Preferred Stock 7.39 13,253 13,253 0.00 82 98 19.51
2017‑09‑30 13F-HR ABEO / Abeona Therapeutics Inc. 17.05 1,684,364 1,684,364 0.00 10,780 28,718 166.40
2017‑09‑30 13F-HR ALKS / Alkermes plc 50.84 150,251 150,251 0.00 8,710 7,639 -12.30
2017‑09‑30 13F-HR NBRV / Nabriva Therapeutics AG 8.19 350,000 938,235 168.07 3,668 7,684 109.49
2017‑09‑30 13F-HR 74365AAB7 / Protalix BioTherapeutics, Inc. Bonds 4.5% 9/15/18 2,572 2,576 0.16
2017‑09‑30 13F-HR IMDZ / Immune Design Corp. 10.35 148,937 148,937 0.00 1,452 1,541 6.13
2017‑09‑30 13F-HR BPMX / BioPharmX Corporation 0.29 598,758 598,758 0.00 287 171 -40.42
2017‑09‑30 13F-HR 09061GAE1 / BioMarin Pharmaceutical Inc. Bond 0.75% 10/15/2018 13,547 13,634 0.64
2017‑09‑30 13F-HR NTLA / Intellia Therapeutics, Inc. 24.85 1,062,120 1,062,120 0.00 16,994 26,394 55.31
2017‑09‑30 13F-HR RARX / Ra Pharmaceuticals, Inc. 14.60 177,952 177,952 0.00 3,335 2,598 -22.10
2017‑09‑30 13F-HR SBPH / Spring Bank Pharmaceuticals, Inc. 16.84 373,144 373,144 0.00 5,052 6,284 24.39
2017‑09‑30 13F-HR ARGX / argenx SE ADS 22.61 100,000 100,000 0.00 2,121 2,261 6.60
2017‑09‑30 13F-HR NTRA / Natera, Inc. 12.89 228,676 228,676 0.00 2,483 2,948 18.73
2017‑09‑30 13F-HR ZGNX / Zogenix, Inc. 185,290 0 -100.00 2,687 0 -100.00
2017‑09‑30 13F-HR BIVV / Bioverativ Inc. 8,249 0 -100.00 496 0 -100.00
2017‑09‑30 13F-HR CMRX / Chimerix, Inc. 115,216 0 -100.00 628 0 -100.00
2017‑09‑30 13F-HR CRBP / Corbus Pharmaceuticals Holdings, Inc. 130,129 0 -100.00 820 0 -100.00
2017‑09‑30 13F-HR JUNO / Juno Therapeutics, Inc. 50,000 0 -100.00 1,495 0 -100.00
2017‑09‑30 13F-HR ALDR / Alder BioPharmaceuticals, Inc. 217,328 0 -100.00 2,488 0 -100.00
2017‑09‑30 13F-HR PTN / Palatin Technologies, Inc. 2,050,000 0 -100.00 882 0 -100.00
2017‑09‑30 13F-HR MCRB / Seres Therapeutics, Inc. 125,000 0 -100.00 1,413 0 -100.00
2017‑09‑30 13F-HR RARE / Ultragenyx Pharmaceutical Inc. 25,000 0 -100.00 1,553 0 -100.00