InvestorBaker Brothers Advisors LP
ManagerJulian and Felix Baker
Insider ProfileBAKER BROS. ADVISORS LP
Portfolio Value $ 13,308,803,000
Current Positions113
Opened Positions5
Closed Positions6


Latest Holdings, Performance, AUM (from 13F, 13D)

Baker Brothers Advisors LP - Portfolio Value

Baker Brothers Advisors LP has disclosed 113 total holdings in their latest SEC filings. Portfolio manager(s) are listed as Julian and Felix Baker. Most recent portfolio value is calculated to be $ 13,308,803,000 USD. Actual Assets Under Management (AUM) is this value plus cash (which is not disclosed). Baker Brothers Advisors LP's top holdings are Seattle Genetics, Inc. (NASDAQ:SGEN) , Incyte Corp. (NASDAQ:INCY) , BeiGene, Ltd. (NASDAQ:BGNE) , Alexion Pharmaceuticals, Inc. (NASDAQ:ALXN) , and BioMarin Pharmaceutical, Inc. (NASDAQ:BMRN) . Baker Brothers Advisors LP's new positions include Tricida, Inc. (NASDAQ:TCDA) , Novavax, Inc. Bond 3.75% Due 2/1/2023 (670002AB0) , Zymeworks Inc (NYSE:ZYME) , BioMarin Pharmaceutical, Inc. Bond (09061GAH4) , and BioMarin Pharmaceutical Inc. Bond 0.75% 10/15/2018 (09061GAE1) . Baker Brothers Advisors LP's top industries are "Construction Special Trade Contractors" (sic 17) , "Measuring, Analyzing, And Controlling Instruments; Photographic, Medical And Optical Goods; Watches And Clocks" (sic 38) , and "Health Services" (sic 80) .

All Baker Brothers Advisors LP holdings are listed in the following tables. Data is sourced from 13D/13G, 13F, and N-Q filings. Green rows indicate new positions. Red rows indicate closed positions.

This is a list of 13D and 13G filings made since the last quarterly 13F report (if any). Click the link icon to see the full transaction history.

File DateFormSecurity Prev
Shares
Current
Shares
Change
(Percent)
Ownership
Change
(Percent)
2018‑08‑01 SC 13D/A BGNE / BeiGene, Ltd. 155,484,836 155,703,388 0.14 22.30 -0.45
2018‑07‑02 SC 13D/A EYRYY / Erytech Pharma 4,898,337 3,085,969 -37.00 17.20 -37.00

This form was filed on August 14, 2018. Click the link icon to see the full transaction history.

Reporting
Period
Form Security Imputed
Share Price
Prev
Shares
Current
Shares
Change
(Percent)
Prev Value
($1000)
Current Value
($1000)
Change
(Percent)
2018-06-30 13F-HR FTSV / Forty Seven, Inc. 16.00 250,000 4,000
2018-06-30 13F-HR Ritter Pharmaceuticals, Inc. / (767836307) 2.57 279,999 720
2018-06-30 13F-HR Corsicanto II Designated Activity Company / NOTE 3.5% 1/5/2047 (220485AB2) 10,908
2018-06-30 13F-HR 670002AB0 / Novavax, Inc. Bond 3.75% Due 2/1/2023 61,864 42,667 -31.03
2018-06-30 13F-HR AMRN / Amarin Corp. Plc 3.09 22,669,509 22,669,509 0.00 68,235 70,049 2.66
2018-06-30 13F-HR DVAX / Dynavax Technologies Corp. 15.25 75,000 75,000 0.00 1,489 1,144 -23.17
2018-06-30 13F-HR VNDA / Vanda Pharmaceuticals, Inc. 19.05 600,354 310,354 -48.30 10,116 5,912 -41.56
2018-06-30 13F-HR RIGL / Rigel Pharmaceuticals, Inc. 2.83 2,518,882 1,041,612 -58.65 8,917 2,948 -66.94
2018-06-30 13F-HR OVID / Ovid Therapeutics Inc. 7.80 247,733 247,733 0.00 1,751 1,932 10.34
2018-06-30 13F-HR IFRX / InflaRx N.V. 32.25 200,000 258,824 29.41 5,768 8,347 44.71
2018-06-30 13F-HR MYOK / MyoKardia, Inc. 49.65 290,264 433,121 49.22 14,165 21,504 51.81
2018-06-30 13F-HR BMRN / BioMarin Pharmaceutical, Inc. 94.20 7,583,084 7,583,084 0.00 614,761 714,327 16.20
2018-06-30 13F-HR ACHN / Achillion Pharmaceuticals, Inc. 2.83 2,856,637 1,943,620 -31.96 10,598 5,500 -48.10
2018-06-30 13F-HR QURE / uniQure N.V. 37.80 500,000 605,000 21.00 11,750 22,869 94.63
2018-06-30 13F-HR GWPH / GW Pharmaceuticals Plc. 139.54 221,800 321,800 45.09 24,990 44,904 79.69
2018-06-30 13F-HR SGEN / Seattle Genetics, Inc. 66.39 49,575,409 51,046,060 2.97 2,594,777 3,388,948 30.61
2018-06-30 13F-HR ABUS / Arbutus Biopharma Corporation 7.30 180,582 180,582 0.00 903 1,318 45.96
2018-06-30 13F-HR NVTA / Invitae Corp. 7.35 8,399,411 8,399,411 0.00 39,393 61,736 56.72
2018-06-30 13F-HR GLPG / Galapagos N.V. 92.18 259,894 259,894 0.00 25,927 23,957 -7.60
2018-06-30 13F-HR JNCE / Jounce Therapeutics, Inc. 7.66 100,000 100,000 0.00 2,235 766 -65.73
2018-06-30 13F-HR CCXI / ChemoCentryx, Inc. 13.17 414,029 414,029 0.00 5,631 5,453 -3.16
2018-06-30 13F-HR MNTA / Momenta Pharmaceuticals, Inc. 20.45 308,500 308,500 0.00 5,599 6,309 12.68
2018-06-30 13F-HR SELB / Selecta Biosciences, Inc. 13.25 93,750 93,750 0.00 955 1,242 30.05
2018-06-30 13F-HR SGMO / Sangamo BioSciences, Inc. 14.20 1,607,579 1,283,923 -20.13 30,544 18,232 -40.31
2018-06-30 13F-HR TTPH / Tetraphase Pharmaceuticals, Inc. 3.57 935,000 935,000 0.00 2,870 3,338 16.31
2018-06-30 13F-HR PGNX / Progenics Pharmaceuticals, Inc. 8.04 2,306,184 979,016 -57.55 17,204 7,871 -54.25
2018-06-30 13F-HR BOLD / Audentes Therapeutics, Inc. 38.21 393,222 393,222 0.00 11,816 15,025 27.16
2018-06-30 13F-HR INSM / Insmed, Inc. 23.65 700,000 700,000 0.00 15,764 16,555 5.02
2018-06-30 13F-HR GHDX / Genomic Health, Inc. 50.40 13,789,936 13,790,574 0.00 431,487 695,045 61.08
2018-06-30 13F-HR GLYC / GlycoMimetics, Inc. 16.13 563,312 291,214 -48.30 9,143 4,697 -48.63
2018-06-30 13F-HR CERS / Cerus Corp. 6.67 10,749,937 10,749,937 0.00 58,910 71,702 21.71
2018-06-30 13F-HR ANAB / AnaptysBio, Inc. 71.04 91,086 73,086 -19.76 9,480 5,192 -45.23
2018-06-30 13F-HR 00767EAB8 / Aegerion Pharmaceuticals, Inc. 2.0% Bond due 2019-08-15 7,273 6,027 -17.13
2018-06-30 13F-HR ACAD / ACADIA Pharmaceuticals, Inc. 15.27 27,228,338 27,228,338 0.00 611,821 415,777 -32.04
2018-06-30 13F-HR FOMX / Foamix Pharmaceuticals Ltd. 5.01 1,598,991 1,490,201 -6.80 8,203 7,466 -8.98
2018-06-30 13F-HR CLLS / Cellectis S.A. 28.30 50,000 50,000 0.00 1,576 1,415 -10.22
2018-06-30 13F-HR BTX.WS / BioTime, Inc. Warrants exp. 2018-10-01 0.05 20,084 20,084 0.00 2 1 -50.00
2018-06-30 13F-HR AERI / Aerie Pharmaceuticals, Inc. 67.54 215,655 60,155 -72.11 11,699 4,063 -65.27
2018-06-30 13F-HR MDGN / Medgenics, Inc. 1.11 4,055,142 4,055,142 0.00 8,151 4,501 -44.78
2018-06-30 13F-HR INCY / Incyte Corp. 67.00 34,230,751 34,251,034 0.06 2,852,448 2,294,819 -19.55
2018-06-30 13F-HR MNLO / Menlo Therapeutics Inc. 8.12 700,000 700,000 0.00 26,306 5,684 -78.39
2018-06-30 13F-HR VSAR / Versartis, Inc.. 2.02 1,426,310 2,426,310 70.11 2,353 4,913 108.80
2018-06-30 13F-HR BLCM / Bellicum Pharmaceuticals, Inc. 7.38 4,151,578 4,093,447 -1.40 27,234 30,210 10.93
2018-06-30 13F-HR INFI / Infinity Pharmaceuticals, Inc. 1.91 580,400 580,400 0.00 1,219 1,109 -9.02
2018-06-30 13F-HR NBIX / Neurocrine Biosciences, Inc. 98.24 944,624 944,624 0.00 78,338 92,800 18.46
2018-06-30 13F-HR ECYT / Endocyte, Inc. 13.80 2,277,799 2,277,799 0.00 20,705 31,434 51.82
2018-06-30 13F-HR BCRX / BioCryst Pharmaceuticals, Inc. 5.73 14,012,172 14,012,172 0.00 66,838 80,290 20.13
2018-06-30 13F-HR CBAY / Cymabay Therapeutics Inc. 13.42 3,917,700 4,917,700 25.53 50,891 65,996 29.68
2018-06-30 13F-HR ACOR / Acorda Therapeutics, Inc. 28.70 0 173,100 0 4,968
2018-06-30 13F-HR XLRN / Acceleron Pharma Inc. 48.52 163,900 163,900 0.00 6,408 7,952 24.09
2018-06-30 13F-HR SNSS / Sunesis Pharmaceuticals, Inc. 2.12 556,665 556,665 0.00 1,514 1,180 -22.06
2018-06-30 13F-HR STML / Stemline Therapeutics, Inc. 16.06 287,827 44,524 -84.53 4,404 715 -83.76
2018-06-30 13F-HR SYRS / Syros Pharmaceuticals, Inc. 10.21 574,835 574,835 0.00 7,461 5,869 -21.34
2018-06-30 13F-HR NLNK / NewLink Genetics Corp 4.76 507,273 507,273 0.00 3,678 2,415 -34.34
2018-06-30 13F-HR LJPC / La Jolla Pharmaceutical Co. 29.17 154,675 154,675 0.00 4,606 4,512 -2.04
2018-06-30 13F-HR AIMT / Aimmune Therapeutics, Inc. 26.89 673,908 673,908 0.00 21,450 18,121 -15.52
2018-06-30 13F-HR BIOD / Biodel, Inc. 35.50 250,000 250,000 0.00 8,143 8,875 8.99
2018-06-30 13F-HR HRTX / Heron Therapeutics, Inc. 38.85 5,025,298 5,025,298 0.00 138,698 195,233 40.76
2018-06-30 13F-HR CRBP / Corbus Pharmaceuticals Holdings, Inc. 5.05 660,714 247,450 -62.55 4,030 1,250 -68.98
2018-06-30 13F-HR ALXN / Alexion Pharmaceuticals, Inc. 124.15 8,555,894 8,555,894 0.00 953,640 1,062,214 11.39
2018-06-30 13F-HR ASMB / Assembly Biosciences, Inc. 39.21 193,787 148,587 -23.32 9,523 5,826 -38.82
2018-06-30 13F-HR ONCE / Spark Therapeutics, Inc. 82.76 1,384,130 1,384,130 0.00 92,169 114,551 24.28
2018-06-30 13F-HR MRUS / Merus N.V. 22.76 1,160,014 1,160,014 0.00 21,495 26,402 22.83
2018-06-30 13F-HR FLGT / Fulgent Genetics, Inc. 4.14 125,000 125,000 0.00 500 518 3.60
2018-06-30 13F-HR GTHX / G1 Therapeutics, Inc. 43.46 169,492 169,492 0.00 6,280 7,366 17.29
2018-06-30 13F-HR AKTX / Akari Therapeutics Plc 1.96 339,833 58,770 -82.71 618 115 -81.39
2018-06-30 13F-HR ADMS / Adamas Pharmaceuticals, Inc. 25.83 172,630 172,630 0.00 4,126 4,459 8.07
2018-06-30 13F-HR AQXP / Aquinox Pharmaceuticals, Inc. 2.65 10,934,154 10,934,154 0.00 153,953 28,976 -81.18
2018-06-30 13F-HR MDWD / MediWound Ltd. 6.90 226,000 226,000 0.00 1,175 1,559 32.68
2018-06-30 13F-HR THLD / Threshold Pharmaceuticals, Inc. 5.23 72,412 72,412 0.00 579 379 -34.54
2018-06-30 13F-HR TTOO / T2 Biosystems, Inc. 7.74 100,000 100,000 0.00 649 774 19.26
2018-06-30 13F-HR BLUE / bluebird bio, Inc. 156.95 200,000 200,000 0.00 34,150 31,390 -8.08
2018-06-30 13F-HR BDSI / BioDelivery Sciences International, Inc. 2.95 210,021 210,021 0.00 473 620 31.08
2018-06-30 13F-HR ASND / Ascendis Pharma AS 66.52 2,837,352 2,837,352 0.00 185,563 188,741 1.71
2018-06-30 13F-HR DBVT / DBV Technologies S.A. 19.29 5,509,560 5,509,560 0.00 127,106 106,279 -16.39
2018-06-30 13F-HR CPRX / Catalyst Pharmaceuticals, Inc. 3.12 4,381,072 3,621,962 -17.33 10,471 11,301 7.93
2018-06-30 13F-HR AGLE / Aeglea BioTherapeutics, Inc. 10.58 1,137,872 1,387,872 21.97 11,288 14,684 30.09
2018-06-30 13F-HR TRVN / Trevena, Inc. 1.44 950,000 950,000 0.00 1,558 1,368 -12.20
2018-06-30 13F-HR AFMD / Affimed N.V. 1.65 400,000 400,000 0.00 740 660 -10.81
2018-06-30 13F-HR SLDB / Solid Biosciences Inc 35.63 587,884 587,884 0.00 4,409 20,946 375.07
2018-06-30 13F-HR CFRX / ContraFect Corporation 2.21 7,153,076 7,153,076 0.00 11,625 15,808 35.98
2018-06-30 13F-HR KRYS / Krystal Biotech, Inc. 14.87 200,000 200,000 0.00 2,018 2,974 47.37
2018-06-30 13F-HR EXEL / Exelixis, Inc. 21.52 1,162,644 513,410 -55.84 25,753 11,049 -57.10
2018-06-30 13F-HR TNXP / Tonix Pharmaceuticals Holding Corp. 4.45 699,500 699,500 0.00 2,098 3,113 48.38
2018-06-30 13F-HR EYRYY / Erytech Pharma 11.17 3,090,069 3,085,969 -0.13 64,891 34,470 -46.88
2018-06-30 13F-HR TRIL / Trillium Therapeutics Inc. 6.00 409,323 511,763 25.03 2,947 3,071 4.21
2018-06-30 13F-HR MRTX / Mirati Therapeutics, Inc. 49.30 2,549,461 2,513,462 -1.41 78,268 123,914 58.32
2018-06-30 13F-HR SNTA / Synta Pharmaceuticals, Inc. 279.69 615,684 1,169,278 89.92 71,906 327,035 354.81
2018-06-30 13F-HR SAGE / Sage Therapeutics, Inc. 156.53 646,828 613,300 -5.18 104,185 96,000 -7.86
2018-06-30 13F-HR MGNX / MacroGenics, Inc. 20.65 363,676 217,695 -40.14 9,150 4,495 -50.87
2018-06-30 13F-HR PRTO / Proteon Therapeutics, Inc. 2.45 298,591 298,591 0.00 746 732 -1.88
2018-06-30 13F-HR ARRY / Array BioPharma, Inc. 16.78 5,656,196 5,656,196 0.00 92,309 94,911 2.82
2018-06-30 13F-HR ADAP / Adaptimmune Therapeutics plc 11.87 100,000 100,000 0.00 1,123 1,187 5.70
2018-06-30 13F-HR HALO / Halozyme Therapeutics, Inc. 16.87 1,581,424 1,283,929 -18.81 30,980 21,660 -30.08
2018-06-30 13F-HR XNCR / Xencor, Inc. 37.01 872,072 872,072 0.00 26,145 32,275 23.45
2018-06-30 13F-HR BGNE / BeiGene, Ltd. 153.73 5,829,429 11,959,824 105.16 979,344 1,838,584 87.74
2018-06-30 13F-HR CYCCP / Cyclacel Pharmaceuticals Inc., 6.00% Convertible Exchangeable Preferred Stock 6.72 13,253 13,253 0.00 77 89 15.58
2018-06-30 13F-HR ABEO / Abeona Therapeutics Inc. 16.00 2,184,364 2,184,364 0.00 31,346 34,950 11.50
2018-06-30 13F-HR ALKS / Alkermes plc 41.16 100,251 100,251 0.00 5,811 4,126 -29.00
2018-06-30 13F-HR NBRV / Nabriva Therapeutics AG 3.48 938,235 938,235 0.00 4,719 3,265 -30.81
2018-06-30 13F-HR CMTA / Clementia Pharmaceuticals Inc. 13.16 250,000 1,192,595 377.04 3,788 15,695 314.33
2018-06-30 13F-HR 09061GAH4 / BioMarin Pharmaceutical, Inc. Bond 14,099 15,198 7.79
2018-06-30 13F-HR 09061GAE1 / BioMarin Pharmaceutical Inc. Bond 0.75% 10/15/2018 12,537 13,000 3.69
2018-06-30 13F-HR NTLA / Intellia Therapeutics, Inc. 27.36 833,795 546,922 -34.41 17,585 14,964 -14.90
2018-06-30 13F-HR RYTM / Rhythm Pharmaceuticals, Inc. 31.26 2,049,020 2,708,200 32.17 40,775 84,658 107.62
2018-06-30 13F-HR RARX / Ra Pharmaceuticals, Inc. 9.95 177,952 177,952 0.00 945 1,771 87.41
2018-06-30 13F-HR SBPH / Spring Bank Pharmaceuticals, Inc. 11.85 373,144 373,144 0.00 5,739 4,422 -22.95
2018-06-30 13F-HR ARGX / argenx SE ADS 82.86 961,754 961,754 0.00 77,363 79,691 3.01
2018-06-30 13F-HR NTRA / Natera, Inc. 18.82 228,676 228,676 0.00 2,120 4,304 103.02
2018-06-30 13F-HR ABYLY / Ablynx NV 2,176,802 0 -100.00 118,766 0 -100.00
2018-06-30 13F-HR AVXS / AveXis, Inc. 1,167,157 0 -100.00 144,237 0 -100.00
2018-06-30 13F-HR NVAX / Novavax, Inc. 2,000,000 0 -100.00 4,200 0 -100.00
2018-06-30 13F-HR IDRA / Idera Pharmaceuticals, Inc. 38,641,462 0 -100.00 71,100 0 -100.00
2018-06-30 13F-HR NKTR / Nektar Therapeutics 275,396 0 -100.00 29,264 0 -100.00
2018-06-30 13F-HR IMDZ / Immune Design Corp. 148,937 0 -100.00 491 0 -100.00
2018-06-30 13F-HR APLS / Apellis Pharmaceuticals, Inc. 22.00 196,078 4,314
2018-06-30 13F-HR RCUS / Arcus Biosciences, Inc. 12.24 121,534 1,488
2018-06-30 13F-HR AUTL / Autolus Therapeutics plc 26.79 235,294 6,304
2018-06-30 13F-HR GLMD / Galmed Pharmaceuticals Ltd. 11.90 636,140 7,570
2018-06-30 13F-HR Idera Pharmaceuticals, Inc. / (45168K405) 1.32 38,654,811 51,024
2018-06-30 13F-HR Kiniksa Pharmaceuticals, Ltd. / COM CL A (G5269C101) 17.35 3,000,000 52,050
2018-06-30 13F-HR SESN / Sesen Bio, Inc. 1.95 2,624,412 5,118
2018-06-30 13F-HR TCDA / Tricida, Inc. 29.90 1,600,000 47,840
2018-06-30 13F-HR ZYME / Zymeworks Inc 14.78 1,311,085 19,378
2018-06-30 13F-HR Neurocrine Biosciences, Inc. / NOTE 2.25% 5/15/2024 (64125CAD1) 14,466