InvestorBaker Brothers Advisors LP
ManagerJulian and Felix Baker
Insider ProfileBAKER BROS. ADVISORS LP
Portfolio Value $ 11,797,988,000
Current Positions108
Opened Positions5
Closed Positions13


Latest Holdings, Performance, AUM (from 13F, 13D)

Baker Brothers Advisors LP - Portfolio Value

Baker Brothers Advisors LP has disclosed 108 total holdings in their latest SEC filings. Portfolio manager(s) are listed as Julian and Felix Baker. Most recent portfolio value is calculated to be $ 11,797,988,000 USD. Actual Assets Under Management (AUM) is this value plus cash (which is not disclosed). Baker Brothers Advisors LP's top holdings are Incyte Corp. (NASDAQ:INCY) , Seattle Genetics, Inc. (NASDAQ:SGEN) , BeiGene, Ltd. (NASDAQ:BGNE) , Alexion Pharmaceuticals, Inc. (NASDAQ:ALXN) , and BioMarin Pharmaceutical, Inc. (NASDAQ:BMRN) . Baker Brothers Advisors LP's new positions include Novavax, Inc. Bond 3.75% Due 2/1/2023 (670002AB0) , Menlo Therapeutics Inc. (NASDAQ:MNLO) , BioMarin Pharmaceutical, Inc. Bond (09061GAH4) , BioMarin Pharmaceutical Inc. Bond 0.75% 10/15/2018 (09061GAE1) , and Audentes Therapeutics, Inc. (NASDAQ:BOLD) . Baker Brothers Advisors LP's top industries are "Construction Special Trade Contractors" (sic 17) , "Measuring, Analyzing, And Controlling Instruments; Photographic, Medical And Optical Goods; Watches And Clocks" (sic 38) , and "Health Services" (sic 80) .

All Baker Brothers Advisors LP holdings are listed in the following tables. Data is sourced from 13D/13G, 13F, and N-Q filings. Green rows indicate new positions. Red rows indicate closed positions.

This is a list of 13D and 13G filings made since the last quarterly 13F report (if any). Click the link icon to see the full transaction history.

File DateFormSecurity Prev
Shares
Current
Shares
Change
(Percent)
Ownership
Change
(Percent)
2018‑05‑31 SC 13D KNSA / Kiniksa Pharmaceuticals, Ltd. Class A 3,006,252 20.40
2018‑05‑10 SC 13G/A BLCM / Bellicum Pharmaceuticals, Inc. 5,032,313 4,151,578 -17.50 9.70 -36.18
2018‑05‑03 SC 13D/A INCY / Incyte Corp. 34,404,580 34,520,320 0.34 16.30 -2.98
2018‑05‑02 SC 13D/A SGEN / Seattle Genetics, Inc. 49,818,661 50,831,621 2.03 32.10 1.26
2018‑04‑10 SC 13G NVTA / Invitae Corp. 7,288,300 8,399,411 15.25 12.60 -16.56

This form was filed on May 15, 2018. Click the link icon to see the full transaction history.

Reporting
Period
Form Security Imputed
Share Price
Prev
Shares
Current
Shares
Change
(Percent)
Prev Value
($1000)
Current Value
($1000)
Change
(Percent)
2018-03-31 13F-HR TTPH / Tetraphase Pharmaceuticals, Inc. 3.07 935,000 935,000 0.00 5,891 2,870 -51.28
2018-03-31 13F-HR 00767EAB8 / Aegerion Pharmaceuticals, Inc. 2.0% Bond due 2019-08-15 7,566 7,273 -3.87
2018-03-31 13F-HR FOMX / Foamix Pharmaceuticals Ltd. 5.13 2,466,702 1,598,991 -35.18 14,825 8,203 -44.67
2018-03-31 13F-HR CLLS / Cellectis S.A. 31.52 50,000 50,000 0.00 1,458 1,576 8.09
2018-03-31 13F-HR AKTX / Akari Therapeutics Plc 1.82 696,901 339,833 -51.24 3,018 618 -79.52
2018-03-31 13F-HR DBVT / DBV Technologies S.A. 23.07 5,509,560 5,509,560 0.00 135,535 127,106 -6.22
2018-03-31 13F-HR 09061GAE1 / BioMarin Pharmaceutical Inc. Bond 0.75% 10/15/2018 13,218 12,537 -5.15
2018-03-31 13F-HR NTLA / Intellia Therapeutics, Inc. 21.09 1,145,453 833,795 -27.21 22,016 17,585 -20.13
2018-03-31 13F-HR ACHN / Achillion Pharmaceuticals, Inc. 3.71 2,856,637 2,856,637 0.00 8,227 10,598 28.82
2018-03-31 13F-HR BCRX / BioCryst Pharmaceuticals, Inc. 4.77 13,997,172 14,012,172 0.11 68,726 66,838 -2.75
2018-03-31 13F-HR GLPG / Galapagos N.V. 99.76 259,894 259,894 0.00 24,368 25,927 6.40
2018-03-31 13F-HR GHDX / Genomic Health, Inc. 31.29 13,781,102 13,789,936 0.06 471,314 431,487 -8.45
2018-03-31 13F-HR GWPH / GW Pharmaceuticals Plc. 112.67 221,800 221,800 0.00 29,280 24,990 -14.65
2018-03-31 13F-HR GLYC / GlycoMimetics, Inc. 16.23 563,312 563,312 0.00 9,458 9,143 -3.33
2018-03-31 13F-HR HRTX / Heron Therapeutics, Inc. 27.60 3,060,641 5,025,298 64.19 55,398 138,698 150.37
2018-03-31 13F-HR OVID / Ovid Therapeutics Inc. 7.07 333,333 247,733 -25.68 3,290 1,751 -46.78
2018-03-31 13F-HR VNDA / Vanda Pharmaceuticals, Inc. 16.85 423,884 600,354 41.63 6,443 10,116 57.01
2018-03-31 13F-HR 670002AB0 / Novavax, Inc. Bond 3.75% Due 2/1/2023 40,863 61,864 51.39
2018-03-31 13F-HR AMRN / Amarin Corp. Plc 3.01 22,669,509 22,669,509 0.00 90,905 68,235 -24.94
2018-03-31 13F-HR DVAX / Dynavax Technologies Corp. 19.85 75,000 75,000 0.00 1,403 1,489 6.13
2018-03-31 13F-HR RIGL / Rigel Pharmaceuticals, Inc. 3.54 2,518,882 2,518,882 0.00 9,773 8,917 -8.76
2018-03-31 13F-HR IFRX / InflaRx N.V. 28.84 200,000 200,000 0.00 4,190 5,768 37.66
2018-03-31 13F-HR MYOK / MyoKardia, Inc. 48.80 355,264 290,264 -18.30 14,957 14,165 -5.30
2018-03-31 13F-HR BMRN / BioMarin Pharmaceutical, Inc. 81.07 7,583,084 7,583,084 0.00 676,184 614,761 -9.08
2018-03-31 13F-HR QURE / uniQure N.V. 23.50 482,557 500,000 3.61 9,453 11,750 24.30
2018-03-31 13F-HR SGEN / Seattle Genetics, Inc. 52.34 45,725,556 49,575,409 8.42 2,446,317 2,594,777 6.07
2018-03-31 13F-HR ABUS / Arbutus Biopharma Corporation 5.00 180,582 180,582 0.00 912 903 -0.99
2018-03-31 13F-HR ABYLY / Ablynx NV 54.56 4,161,118 2,176,802 -47.69 103,986 118,766 14.21
2018-03-31 13F-HR NVTA / Invitae Corp. 4.69 7,288,300 8,399,411 15.25 66,178 39,393 -40.47
2018-03-31 13F-HR JNCE / Jounce Therapeutics, Inc. 22.35 100,000 100,000 0.00 1,275 2,235 75.29
2018-03-31 13F-HR CCXI / ChemoCentryx, Inc. 13.60 49,064 414,029 743.85 292 5,631 1,828.42
2018-03-31 13F-HR SELB / Selecta Biosciences, Inc. 10.19 283,716 93,750 -66.96 2,783 955 -65.68
2018-03-31 13F-HR SGMO / Sangamo BioSciences, Inc. 19.00 2,113,376 1,607,579 -23.93 34,659 30,544 -11.87
2018-03-31 13F-HR PGNX / Progenics Pharmaceuticals, Inc. 7.46 3,150,808 2,306,184 -26.81 18,747 17,204 -8.23
2018-03-31 13F-HR INSM / Insmed, Inc. 22.52 700,000 700,000 0.00 21,826 15,764 -27.77
2018-03-31 13F-HR CERS / Cerus Corp. 5.48 9,745,209 10,749,937 10.31 32,939 58,910 78.85
2018-03-31 13F-HR ANAB / AnaptysBio, Inc. 104.08 181,386 91,086 -49.78 18,269 9,480 -48.11
2018-03-31 13F-HR ACAD / ACADIA Pharmaceuticals, Inc. 22.47 27,228,338 27,228,338 0.00 819,845 611,821 -25.37
2018-03-31 13F-HR BTX.WS / BioTime, Inc. Warrants exp. 2018-10-01 0.10 20,084 20,084 0.00 2 2 0.00
2018-03-31 13F-HR AERI / Aerie Pharmaceuticals, Inc. 54.25 299,356 215,655 -27.96 17,887 11,699 -34.59
2018-03-31 13F-HR MDGN / Medgenics, Inc. 2.01 4,055,142 4,055,142 0.00 4,866 8,151 67.51
2018-03-31 13F-HR INCY / Incyte Corp. 83.33 34,230,523 34,230,751 0.00 3,241,973 2,852,448 -12.02
2018-03-31 13F-HR VSAR / Versartis, Inc.. 1.65 1,426,310 1,426,310 0.00 3,138 2,353 -25.02
2018-03-31 13F-HR BLCM / Bellicum Pharmaceuticals, Inc. 6.56 5,032,313 4,151,578 -17.50 42,322 27,234 -35.65
2018-03-31 13F-HR INFI / Infinity Pharmaceuticals, Inc. 2.10 580,400 580,400 0.00 1,178 1,219 3.48
2018-03-31 13F-HR NBIX / Neurocrine Biosciences, Inc. 82.93 1,004,624 944,624 -5.97 77,949 78,338 0.50
2018-03-31 13F-HR ECYT / Endocyte, Inc. 9.09 1,087,323 2,277,799 109.49 4,654 20,705 344.89
2018-03-31 13F-HR CBAY / Cymabay Therapeutics Inc. 12.99 2,991,775 3,917,700 30.95 27,524 50,891 84.90
2018-03-31 13F-HR XLRN / Acceleron Pharma Inc. 39.10 163,900 163,900 0.00 6,956 6,408 -7.88
2018-03-31 13F-HR SNSS / Sunesis Pharmaceuticals, Inc. 2.72 741,665 556,665 -24.94 2,737 1,514 -44.68
2018-03-31 13F-HR STML / Stemline Therapeutics, Inc. 15.30 633,497 287,827 -54.57 9,883 4,404 -55.44
2018-03-31 13F-HR SYRS / Syros Pharmaceuticals, Inc. 12.98 574,835 574,835 0.00 5,593 7,461 33.40
2018-03-31 13F-HR NLNK / NewLink Genetics Corp 7.25 1,007,273 507,273 -49.64 8,169 3,678 -54.98
2018-03-31 13F-HR LJPC / La Jolla Pharmaceutical Co. 29.78 154,675 154,675 0.00 4,977 4,606 -7.45
2018-03-31 13F-HR AIMT / Aimmune Therapeutics, Inc. 31.83 673,908 673,908 0.00 25,487 21,450 -15.84
2018-03-31 13F-HR BIOD / Biodel, Inc. 32.57 200,000 250,000 25.00 5,120 8,143 59.04
2018-03-31 13F-HR CRBP / Corbus Pharmaceuticals Holdings, Inc. 6.10 660,714 660,714 0.00 4,691 4,030 -14.09
2018-03-31 13F-HR ALXN / Alexion Pharmaceuticals, Inc. 111.46 8,553,864 8,555,894 0.02 1,022,957 953,640 -6.78
2018-03-31 13F-HR ASMB / Assembly Biosciences, Inc. 49.14 322,727 193,787 -39.95 14,603 9,523 -34.79
2018-03-31 13F-HR MRUS / Merus N.V. 18.53 1,160,014 1,160,014 0.00 22,504 21,495 -4.48
2018-03-31 13F-HR ONCE / Spark Therapeutics, Inc. 66.59 1,384,130 1,384,130 0.00 71,172 92,169 29.50
2018-03-31 13F-HR FLGT / Fulgent Genetics, Inc. 4.00 125,000 125,000 0.00 548 500 -8.76
2018-03-31 13F-HR ADMS / Adamas Pharmaceuticals, Inc. 23.90 172,630 172,630 0.00 5,850 4,126 -29.47
2018-03-31 13F-HR AQXP / Aquinox Pharmaceuticals, Inc. 14.08 10,934,154 10,934,154 0.00 128,586 153,953 19.73
2018-03-31 13F-HR MDWD / MediWound Ltd. 5.20 226,000 226,000 0.00 1,006 1,175 16.80
2018-03-31 13F-HR THLD / Threshold Pharmaceuticals, Inc. 8.00 72,412 72,412 0.00 726 579 -20.25
2018-03-31 13F-HR TTOO / T2 Biosystems, Inc. 6.49 100,000 100,000 0.00 412 649 57.52
2018-03-31 13F-HR BLUE / bluebird bio, Inc. 170.75 200,000 200,000 0.00 35,620 34,150 -4.13
2018-03-31 13F-HR BDSI / BioDelivery Sciences International, Inc. 2.25 210,021 210,021 0.00 620 473 -23.71
2018-03-31 13F-HR ASND / Ascendis Pharma AS 65.40 2,618,818 2,837,352 8.34 104,910 185,563 76.88
2018-03-31 13F-HR CPRX / Catalyst Pharmaceuticals, Inc. 2.39 5,852,153 4,381,072 -25.14 22,882 10,471 -54.24
2018-03-31 13F-HR AGLE / Aeglea BioTherapeutics, Inc. 9.92 1,137,872 1,137,872 0.00 6,156 11,288 83.37
2018-03-31 13F-HR TRVN / Trevena, Inc. 1.64 950,000 950,000 0.00 1,520 1,558 2.50
2018-03-31 13F-HR AFMD / Affimed N.V. 1.85 400,000 400,000 0.00 520 740 42.31
2018-03-31 13F-HR 45780VAB8 / Inotek Pharmaceuticals Corporation Bonds 5.75% 8/1/2021 4,009 4,795 19.61
2018-03-31 13F-HR CFRX / ContraFect Corporation 1.63 7,153,076 7,153,076 0.00 7,225 11,625 60.90
2018-03-31 13F-HR AVXS / AveXis, Inc. 123.58 775,000 1,167,157 50.60 85,769 144,237 68.17
2018-03-31 13F-HR KRYS / Krystal Biotech, Inc. 10.09 200,000 200,000 0.00 2,104 2,018 -4.09
2018-03-31 13F-HR EXEL / Exelixis, Inc. 22.15 1,506,499 1,162,644 -22.82 45,798 25,753 -43.77
2018-03-31 13F-HR NVAX / Novavax, Inc. 2.10 2,000,000 2,000,000 0.00 2,480 4,200 69.35
2018-03-31 13F-HR TNXP / Tonix Pharmaceuticals Holding Corp. 3.00 699,500 699,500 0.00 2,413 2,098 -13.05
2018-03-31 13F-HR EYRYY / Erytech Pharma 21.00 3,090,069 3,090,069 0.00 68,043 64,891 -4.63
2018-03-31 13F-HR TRIL / Trillium Therapeutics Inc. 7.20 409,323 409,323 0.00 2,968 2,947 -0.71
2018-03-31 13F-HR MRTX / Mirati Therapeutics, Inc. 30.70 2,549,461 2,549,461 0.00 46,528 78,268 68.22
2018-03-31 13F-HR SNTA / Synta Pharmaceuticals, Inc. 116.79 615,684 615,684 0.00 56,514 71,906 27.24
2018-03-31 13F-HR SAGE / Sage Therapeutics, Inc. 161.07 616,514 646,828 4.92 101,546 104,185 2.60
2018-03-31 13F-HR IDRA / Idera Pharmaceuticals, Inc. 1.84 18,315,802 38,641,462 110.97 38,646 71,100 83.98
2018-03-31 13F-HR MGNX / MacroGenics, Inc. 25.16 363,676 363,676 0.00 6,910 9,150 32.42
2018-03-31 13F-HR PRTO / Proteon Therapeutics, Inc. 2.50 298,591 298,591 0.00 567 746 31.57
2018-03-31 13F-HR ARRY / Array BioPharma, Inc. 16.32 5,656,196 5,656,196 0.00 72,399 92,309 27.50
2018-03-31 13F-HR ADAP / Adaptimmune Therapeutics plc 11.23 100,000 100,000 0.00 668 1,123 68.11
2018-03-31 13F-HR HALO / Halozyme Therapeutics, Inc. 19.59 1,581,424 1,581,424 0.00 32,040 30,980 -3.31
2018-03-31 13F-HR XNCR / Xencor, Inc. 29.98 872,072 872,072 0.00 19,116 26,145 36.77
2018-03-31 13F-HR BGNE / BeiGene, Ltd. 168.00 3,849,231 5,829,429 51.44 376,147 979,344 160.36
2018-03-31 13F-HR NKTR / Nektar Therapeutics 106.26 171,934 275,396 60.18 10,268 29,264 185.00
2018-03-31 13F-HR CYCCP / Cyclacel Pharmaceuticals Inc., 6.00% Convertible Exchangeable Preferred Stock 5.81 13,253 13,253 0.00 92 77 -16.30
2018-03-31 13F-HR ABEO / Abeona Therapeutics Inc. 14.35 1,984,364 2,184,364 10.08 31,452 31,346 -0.34
2018-03-31 13F-HR ALKS / Alkermes plc 57.96 150,251 100,251 -33.28 8,223 5,811 -29.33
2018-03-31 13F-HR NBRV / Nabriva Therapeutics AG 5.03 938,235 938,235 0.00 5,611 4,719 -15.90
2018-03-31 13F-HR CMTA / Clementia Pharmaceuticals Inc. 15.15 250,000 250,000 0.00 4,745 3,788 -20.17
2018-03-31 13F-HR 09061GAH4 / BioMarin Pharmaceutical, Inc. Bond 14,928 14,099 -5.55
2018-03-31 13F-HR IMDZ / Immune Design Corp. 3.30 148,937 148,937 0.00 581 491 -15.49
2018-03-31 13F-HR RTTR / Ritter Pharmaceuticals, Inc. 2.72 2,800,000 279,999 -90.00 922 762 -17.35
2018-03-31 13F-HR RYTM / Rhythm Pharmaceuticals, Inc. 19.90 2,049,020 2,049,020 0.00 59,545 40,775 -31.52
2018-03-31 13F-HR RARX / Ra Pharmaceuticals, Inc. 5.31 177,952 177,952 0.00 1,513 945 -37.54
2018-03-31 13F-HR SBPH / Spring Bank Pharmaceuticals, Inc. 15.38 373,144 373,144 0.00 5,015 5,739 14.44
2018-03-31 13F-HR ARGX / argenx SE ADS 80.44 961,754 961,754 0.00 60,725 77,363 27.40
2018-03-31 13F-HR NTRA / Natera, Inc. 9.27 228,676 228,676 0.00 2,056 2,120 3.11
2018-03-31 13F-HR AAAP / Advanced Accelerator Applications S.A 55,125 0 -100.00 4,499 0 -100.00
2018-03-31 13F-HR KPTI / Karyopharm Therapeutics Inc. 216,990 0 -100.00 2,083 0 -100.00
2018-03-31 13F-HR AGIO / Agios Pharmaceuticals, Inc. 128,666 0 -100.00 7,356 0 -100.00
2018-03-31 13F-HR RXDX / Ignyta, Inc. 1,384,266 0 -100.00 36,960 0 -100.00
2018-03-31 13F-HR ACOR / Acorda Therapeutics, Inc. 205,966 0 -100.00 4,418 0 -100.00
2018-03-31 13F-HR AKAO / Achaogen, Inc. 122,482 0 -100.00 1,315 0 -100.00
2018-03-31 13F-HR FPRX / Five Prime Therapeutics, Inc. 19,247 0 -100.00 422 0 -100.00
2018-03-31 13F-HR EPZM / Epizyme, Inc. 232,481 0 -100.00 2,918 0 -100.00
2018-03-31 13F-HR NVIV / InVivo Therapeutics Holdings Corp 331,393 0 -100.00 255 0 -100.00
2018-03-31 13F-HR LGND / Ligand Pharmaceuticals Incorporated 73,386 0 -100.00 10,049 0 -100.00
2018-03-31 13F-HR IMGN / Immunogen, Inc. 2,563,489 0 -100.00 16,432 0 -100.00
2018-03-31 13F-HR ITCI / Intra-Cellular Therapies Inc. 609,166 0 -100.00 8,821 0 -100.00
2018-03-31 13F-HR TENX / Tenax Therapeutics, Inc. 348,374 0 -100.00 171 0 -100.00
2018-03-31 13F-HR GTHX / G1 Therapeutics, Inc. 37.05 169,492 6,280
2018-03-31 13F-HR BOLD / Audentes Therapeutics, Inc. 30.05 393,222 11,816
2018-03-31 13F-HR MNLO / Menlo Therapeutics Inc. 37.58 700,000 26,306
2018-03-31 13F-HR MNTA / Momenta Pharmaceuticals, Inc. 18.15 308,500 5,599
2018-03-31 13F-HR SLDB / Solid Biosciences Inc 7.50 587,884 4,409
2018-03-31 13F-HR Corsicanto II Designated Activity Company / Note 3.5% 1/5/2047 (220485AB2) 11,025